@article{oai:nagasaki-u.repo.nii.ac.jp:00018103,
 author = {Matsuu, Mutsumi and Shichijo, Kazuko and Okaichi, Kumio and Wen, Chun Yang and Fukuda, Eiichiro and Nakashima, Masahiro and Nakayama, Toshiyuki and Shirahata, Sanetaka and Tokumaru, Sennosuke and Sekine, Ichiro},
 issue = {2},
 journal = {Journal of radiation research},
 month = {Jun},
 note = {To evaluate the effect of fermented milk kefir on X-ray-induced apoptosis in the colon of rats, we examined the apoptotic index, the mean number of apoptotic cells detected by H&E staining per crypt in the colon, in control rats and kefir-pretreated rats drinking kefir for 12 days before irradiation. Apoptotic cells were confirmed by TUNEL staining, and active caspase-3 expression was studied by immunohistochemistry. The cell position of apoptotic cells and active caspase-3 positive cells were examined. The apoptotic index of kefirtreated rats was significantly (p < 0.05) decreased 2 h after 1 Gy irradiation in comparison with control rats at crypt cell positions 1-3, 5-7, 13, and 15. Active caspase-3 expression in the kefir-treated rats was also significantly (p < 0.05) reduced in comparison with control rats 2 h after 1 Gy irradiation at crypt cell positions 1-4, 13, and 15. This study indicated that kefir protects colonic crypt cells against radiation-induced apoptosis, which was most pronounced in the stem cell region of the crypt. The antiapoptotic effect of fermented milk kefir was due to the inhibition of caspase-3 activation., Journal of radiation research. 2003, 44(2), p.111-115},
 pages = {111--115},
 title = {The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats},
 volume = {44},
 year = {2003}
}