{"created":"2023-05-15T16:42:56.973842+00:00","id":18103,"links":{},"metadata":{"_buckets":{"deposit":"64775ba9-c4c4-45aa-a652-70842d8757d2"},"_deposit":{"created_by":2,"id":"18103","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18103"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018103","sets":["10:11"]},"author_link":["71963","71961","71968","71960","71966","71967","71969","71965","71964","71962"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"115","bibliographicPageStart":"111","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To evaluate the effect of fermented milk kefir on X-ray-induced apoptosis in the colon of rats, we examined the apoptotic index, the mean number of apoptotic cells detected by H&E staining per crypt in the colon, in control rats and kefir-pretreated rats drinking kefir for 12 days before irradiation. Apoptotic cells were confirmed by TUNEL staining, and active caspase-3 expression was studied by immunohistochemistry. The cell position of apoptotic cells and active caspase-3 positive cells were examined. The apoptotic index of kefirtreated rats was significantly (p < 0.05) decreased 2 h after 1 Gy irradiation in comparison with control rats at crypt cell positions 1-3, 5-7, 13, and 15. Active caspase-3 expression in the kefir-treated rats was also significantly (p < 0.05) reduced in comparison with control rats 2 h after 1 Gy irradiation at crypt cell positions 1-4, 13, and 15. This study indicated that kefir protects colonic crypt cells against radiation-induced apoptosis, which was most pronounced in the stem cell region of the crypt. The antiapoptotic effect of fermented milk kefir was due to the inhibition of caspase-3 activation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 2003, 44(2), p.111-115","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuu, Mutsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shichijo, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okaichi, Kumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wen, Chun Yang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Eiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirahata, Sanetaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokumaru, Sennosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekine, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR44_2_111_115.pdf","filesize":[{"value":"945.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR44_2_111_115.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18103/files/RR44_2_111_115.pdf"},"version_id":"e6d6bfd0-e8fb-4d49-90ee-3bf877c57d5b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Kefir","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiation-induced apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"X-ray","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_scheme":"Other"},{"subitem_subject":"Colon","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-12"},"publish_date":"2008-08-12","publish_status":"0","recid":"18103","relation_version_is_last":true,"title":["The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:09:44.728187+00:00"}