{"created":"2023-05-15T16:42:57.974808+00:00","id":18126,"links":{},"metadata":{"_buckets":{"deposit":"6a216162-6faf-44f9-9a74-4a7eccb140ba"},"_deposit":{"created_by":2,"id":"18126","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18126"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018126","sets":["10:11"]},"author_link":["72084","72087","72086","72082","72083","72085"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"110","bibliographicPageStart":"105","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the delayed induction of telomere instability in hTERT-immortalized normal human fibroblast (BJl-hTERT) cells exposed to X-rays. BJl-hTERT cells were irradiated with 2 Gy of X-rays, and chromosome aberrations were analyzed 24 hours after irradiation and in the surviving cells 14 days after X-ray exposure. We found that the X-ray-surviving cells showed an increased frequency of chromatid gaps and breaks and chromosome fragments compared to the control cells. Furthermore, centromere- and telomere-FISH revealed that the frequency of telomere loss and duplication significantly increased in surviving cells compared to the control level. Because no induction of telomere abnormality was observed in cells 24 hours after irradiation, X-irradiation might not affect telomeres directly, but it specifically induces delayed telomere instability in normal human fibroblast cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 2004, 45(1), p.105-110","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ojima, Mitsuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamano, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kodama, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Masami"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR45_1_105_110.pdf","filesize":[{"value":"566.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR45_1_105_110.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18126/files/RR45_1_105_110.pdf"},"version_id":"6c5ca2f9-3344-4ab1-873d-4c6156ce6c76"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ionizing radiation  Genomic instability  Normal human cells  Telomere","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-12"},"publish_date":"2008-08-12","publish_status":"0","recid":"18126","relation_version_is_last":true,"title":["Delayed Induction of Telomere Instability in Normal Human Fibroblast Cells by Ionizing Radiation"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:44.295071+00:00"}