{"created":"2023-05-15T16:42:58.142967+00:00","id":18130,"links":{},"metadata":{"_buckets":{"deposit":"cf1cb276-b9bd-412f-ba9b-305c79fe9fc4"},"_deposit":{"created_by":2,"id":"18130","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18130"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018130","sets":["10:11"]},"author_link":["72105","72106","72104","72108","72107"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-12-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"414","bibliographicPageStart":"407","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Werner syndrome (WS) is an autosomal recessive disease characterized by multiple progeroid features. The gene responsible for WS, WRN, is a member of the human RecQ helicase family. WRN is unique among this family, associated with an exonuclease activity. In the present study, we established the human 293-derived cell lines, which expressed exogenously truncated WRN protein, lacking the N-terminal exonuclease domain but having normal helicase activity, and found that they were slightly, but nonetheless significantly, radiosensitive than control cell lines, into which the empty vector had been introduced. The truncated WRN-expressing cells also exhibited increased numbers of micronuclei, chromosome aberrations, and the foci of phosphorylated histone H2AX with X-rays. These results suggested a function of WRN exonuclease activity that is separable from helicase activity and is essential for the repair of radiation-induced DNA damages.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 2005, 46(4), p.407-414","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kashino, Genro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kodama, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Takehisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Masami"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR46_4_407_414.pdf","filesize":[{"value":"752.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR46_4_407_414.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18130/files/RR46_4_407_414.pdf"},"version_id":"ede3d708-9f83-48f6-8bcb-c5e1c4ce131f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"WRN exonuclease","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiosensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA double-strand breaks","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA repair","subitem_subject_scheme":"Other"},{"subitem_subject":"X-rays","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-12"},"publish_date":"2008-08-12","publish_status":"0","recid":"18130","relation_version_is_last":true,"title":["Exogenous Expression of Exonuclease Domain-deleted WRN Interferes with the Repair of Radiation-induced DNA Damages"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:30.953918+00:00"}