{"created":"2023-05-15T16:42:58.572610+00:00","id":18140,"links":{},"metadata":{"_buckets":{"deposit":"a5ea1a06-789d-48a7-ae33-41f632e126a3"},"_deposit":{"created_by":2,"id":"18140","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18140"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018140","sets":["10:11"]},"author_link":["72157","72159","72160","72158","72161"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement20","bibliographicPageEnd":"85","bibliographicPageStart":"81","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Clinical pediatric endocrinology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We report a case of a 4-yr-old girl with extremely short stature 65 cm (-9.6 SD), low body weight 7.3 kg (-4.6 SD), a characteristic face and hypoglycemia. She did not have her condition diagnosed until she was 4 yr old. She visited our hospital at 4 yr of age when her family moved from Aichi Prefecture. We suspected that she has had complete GH deficiency (CGHD), because her GH value was 0.08 ng/ml at the time of hypoglycemia (BS 35 mg/dl). GRF challenge test showed a peak of GH of 0.2 ng/ml. TRH challenge test showed a peak of TSH of 1.56 IU/mi and a peak of PRL less than 0.5 ng/ml. LH-RH challenge test showed a peak of LH of 3.0 mIU/ml and a peak of FSH of 20.8 mIU/ml. CRH challenge test showed a peak of ACTH of 218 pg/mi and a peak of cortisol of 27.0 ug/dl. The pituitary gland on the brain MRI was normal in size and position. Her bone age was below 1-yr-old by TW-2 RUS. She was diagnosed as having combined pituitary hormone deficiency of GH, TSH and PRL. A common mutation of the Pit-1 gene was detected at R271W in the heterozygous state. A previous paper reported that hypoglycemia was rare in patients with PIT-1 gene mutation but this case experienced hypoglycemia, which was improved after GH and thyroid replacement therapies were started.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Clinical pediatric endocrinology. 2003, 12(Supplement20), p.81-85","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本小児内分泌学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本小児内分泌学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11006467","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09185739","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mochizuki, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Chika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Keinosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kinoshita, Eiichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"CPE12_Suppl20_81_85.pdf","filesize":[{"value":"385.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CPE12_Suppl20_81_85.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18140/files/CPE12_Suppl20_81_85.pdf"},"version_id":"ac3e25ee-2e84-491c-b049-f0ed6abac7fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GH","subitem_subject_scheme":"Other"},{"subitem_subject":"TSH","subitem_subject_scheme":"Other"},{"subitem_subject":"PRL","subitem_subject_scheme":"Other"},{"subitem_subject":"Pit-1 gene mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoglycemia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Four-year-old Girl with Pit-1 Gene Mutation, Extremely Short Stature and Hypoglycemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Four-year-old Girl with Pit-1 Gene Mutation, Extremely Short Stature and Hypoglycemia"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-12"},"publish_date":"2008-08-12","publish_status":"0","recid":"18140","relation_version_is_last":true,"title":["A Four-year-old Girl with Pit-1 Gene Mutation, Extremely Short Stature and Hypoglycemia"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:08:09.162647+00:00"}