{"created":"2023-05-15T16:43:01.026304+00:00","id":18196,"links":{},"metadata":{"_buckets":{"deposit":"674d4108-7d5d-4510-a4ee-7f789033edac"},"_deposit":{"created_by":2,"id":"18196","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18196"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018196","sets":["8:9"]},"author_link":["72526","72522","72525","72523","72524"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"246","bibliographicPageStart":"241","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Oral Oncology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the correlation between the expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and proliferative activity in tumor cells, lymph node metastasis, as well as prognosis in patients with oral squamous cell carcinoma (OSCC). Fifty-seven biopsy specimens of OSCC were investigated for the expression of HIF-1 alpha and proliferating cell nuclear antigen (PCNA) by immunohistochemistry. None of the patients had received any prior treatments. The percentage of HIF-1 alpha immunopositive area (PHIA) was calculated using computer-assisted image analysis for quantitative assessment of HIF-1 alpha expression. The PCNA labeling index (LI) was evaluated as a proliferation marker. We found that the mean PHIA in all stages was 12.1% in the poor prognosis patients, and it was 6.4% in the good prognosis patients. There was a significant difference of PHIA between poor prognosis and good prognosis patients (P = 0.0065). Furthermore, the mean PHIA in the patients who had no metastatic lymph nodes was 7.5%, while it was 11.7% in the patients who had metastatic lymph nodes. There was also a significant difference of PHIA between patients who had no metastatic lymph nodes and those who had metastatic lymph nodes (P = 0.0487). On the other hand, significant correlation between PHIA and PCNA LI was not observed. These results provide the clinical data indicating that HIF-1 alpha may play an important role in lymph node metastasis and prognosis in patients with OSCC.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Oral Oncology, 45(3), pp.241-246; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18675581","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.oraloncology.2008.05.007","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 Elsevier Inc. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10846349","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13688375","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uehara, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sano, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Hisazumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nonaka, Mihoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asahina, Izumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"OraOnc45_241.pdf","filesize":[{"value":"186.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"OraOnc45_241.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18196/files/OraOnc45_241.pdf"},"version_id":"eff57f5b-6542-4401-a83f-8bc9be3a87ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hypoxia-inducible factor 1 alpha","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral squamous cell carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-22"},"publish_date":"2008-08-22","publish_status":"0","recid":"18196","relation_version_is_last":true,"title":["Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:05:45.821687+00:00"}