{"created":"2023-05-15T16:43:01.536890+00:00","id":18208,"links":{},"metadata":{"_buckets":{"deposit":"3f38fd6d-b70f-4bcb-98a2-76bf6378aeeb"},"_deposit":{"created_by":2,"id":"18208","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18208"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018208","sets":["73:74"]},"author_link":["72569","72571","72572","72570","72573"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-08-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"25","bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Molecular Pain"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Among various machineries occurring in the experimental neuropathic pain model, there exists the loss of pain transmission through C-fiber neurons as well as the hypersensitivity through A-fibers. The current study reveals that molecular machineries underlying the latter hypersensitivity are derived from the events through LPA1 receptor and its downstream RhoA-activation following peripheral nerve injury. The loss of C-fiber responses, which are mediated by spinal substance P (SP) pain transmission was observed with the nociceptive flexor responses by intraplantar injection of SP in nerve-injured mice. The immunohistochemistry revealed that SP signal in the dorsal horn was markedly reduced in such mice. All these changes were completely abolished in LPA1-/- mice or by the pretreatment with BoNT/C3, a RhoA inhibitor. In addition, the loss of C-fiber responses and the down-regulation of spinal SP signal induced by single intrathecal LPA injection were also abolished in such treatments. All these results suggest that the loss of pain transmission through polymodal C-fiber neurons is also mediated by the LPA1 activation following nerve injury.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Molecular Pain 2006, 2:25","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"16914035","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1744-8069-2-25","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2006 Inoue et al; licensee BioMed Central Ltd."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12051230","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"17448069","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Asuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chun, Jerold"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"1744-8069-2-25.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"1744-8069-2-25.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18208/files/1744-8069-2-25.pdf"},"version_id":"45abeba9-8d4a-47f7-91b0-728c841da5de"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain"}]},"item_type_id":"2","owner":"2","path":["74"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-27"},"publish_date":"2008-08-27","publish_status":"0","recid":"18208","relation_version_is_last":true,"title":["Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:05:17.895624+00:00"}