@article{oai:nagasaki-u.repo.nii.ac.jp:00018216,
 author = {Chen, Meng and Ssali, Francis and Mulungi, Maureen and Awio, Peter and Yoshimine, Hiroyuki and Kuroki, Reiki and Furumoto, Akitsugu and Tanimura, Susumu and Kityo, Cissy and Nagatake, Tsuyoshi and Mugyenyi, Peter and Oishi, Kazunori},
 issue = {38},
 journal = {Vaccine},
 month = {Sep},
 note = {The levels of IgG determined by ELISA may have limited relevance in human
immunodeficiency virus (HIV)-infected adults because of nonfunctional antibodies. 58
HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate
vaccine (CV) followed by polysaccharide vaccine (PV) after a two-month interval, and
the opsonophagocytic killing (OPK) titers against serotype 4 or 14 pneumococcal
strains as well as the levels of serotype-specific IgG in sera were determined.
Significant increases were found in the OPK titers and IgG levels for both serotypes
after CV vaccination irrespective of HIV status. Increases in IgG levels and OPK titers
were largely dependent on the CD4+ cell counts, except for increases in the IgG levels
for serotype 4. The proportions with serum OPK titer equal to or greater than 8 were
0-4.3% for serotype 4 and 26.7-42.9% for serotype 14 before vaccination, but the
proportions increased up to 43.3-86.2% for serotype 4 and 63.3-96.6% for serotype
14 in all three groups 2 months after CV vaccination. The serum OPK titers remained at
levels higher than the pre-vaccination level for at least 8 months after CV vaccination. A
single dose of CV could afford some protective immunity in HIV-infected African
adults before the introduction of antiretroviral therapy., Vaccine, 26(38), pp.4962-4968; 2008},
 pages = {4962--4968},
 title = {Induction of opsonophagocytic killing activity with pneumococcal conjugate vaccine in human immunodeficiency virus-infected Ugandan adults},
 volume = {26},
 year = {2008}
}