@article{oai:nagasaki-u.repo.nii.ac.jp:00018217,
 author = {Kinugawa, Hidekazu and Sakurai-Yamashita, Yasuko and Niwa, Masami},
 journal = {Brain Research},
 month = {Sep},
 note = {The blood flow in the hippocampus of stroke-prone spontaneously
hypertensive rats (SHRSPs) and Wistar Kyoto (WKY) rats during occlusion of the
carotid arteries was examined because it has been previously found that 2-vessel
occlusion (2-VO) induces delayed neuronal death (DND) in the pyramidal cells of the
CA1 hippocampal area in SHRSPs but not in WKY rats. DND was also examined in
4-week-old SHRSPs, which are as yet normotensive, in order to reveal the involvement
of the development and maintenance of severe hypertension in DND in SHRSPs.
Before, during and after occlusion, the blood flow in the hippocampus was
continuously monitored by laser Doppler flowmetry, wherein the probe was connected
to a plastic fiber that was implanted in the CA1 subfield of animals. The change in
blood flow was determined by comparing its rate during occlusion to the preoperative
value. DND was confirmed by histological examination at 7 days after the operation.
The rate of blood flow during 2-VO was similar between the SHRSPs (42.6% ±
5.3%) and WKY rats (49.0% ± 14.3%). WKY rats that underwent 4-vessel occlusion
(4-VO), which induces DND in WKY rats, exhibited a severely decreased blood flow of
13.7% of the preoperative value. DND was also observed in 4-week-old SHRSPs that
underwent 2-VO, and the incidence was identical to that in 12-week-old SHRSPs.
The present results suggest that the DND that occurs in SHRSPs due to 2-VO
is not a result of the more severe reduction in blood supply during the occlusion than
that in WKY rats, and secondary damage due to severe hypertension but is caused by
some genetic factors due to which the pyramidal neurons of SHRSPs are more
vulnerable to ischemic insult than those of WKY rats are., Brain Research, 1229, pp.204-209; 2008},
 pages = {204--209},
 title = {Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats},
 volume = {1229},
 year = {2008}
}