{"created":"2023-05-15T16:43:01.915205+00:00","id":18217,"links":{},"metadata":{"_buckets":{"deposit":"2a16a1d0-803d-458a-8234-1b01eafe7033"},"_deposit":{"created_by":2,"id":"18217","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18217"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018217","sets":["29:30"]},"author_link":["72624","72623","72622"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"209","bibliographicPageStart":"204","bibliographicVolumeNumber":"1229","bibliographic_titles":[{"bibliographic_title":"Brain Research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The blood flow in the hippocampus of stroke-prone spontaneously\nhypertensive rats (SHRSPs) and Wistar Kyoto (WKY) rats during occlusion of the\ncarotid arteries was examined because it has been previously found that 2-vessel\nocclusion (2-VO) induces delayed neuronal death (DND) in the pyramidal cells of the\nCA1 hippocampal area in SHRSPs but not in WKY rats. DND was also examined in\n4-week-old SHRSPs, which are as yet normotensive, in order to reveal the involvement\nof the development and maintenance of severe hypertension in DND in SHRSPs.\nBefore, during and after occlusion, the blood flow in the hippocampus was\ncontinuously monitored by laser Doppler flowmetry, wherein the probe was connected\nto a plastic fiber that was implanted in the CA1 subfield of animals. The change in\nblood flow was determined by comparing its rate during occlusion to the preoperative\nvalue. DND was confirmed by histological examination at 7 days after the operation.\nThe rate of blood flow during 2-VO was similar between the SHRSPs (42.6% ±\n5.3%) and WKY rats (49.0% ± 14.3%). WKY rats that underwent 4-vessel occlusion\n(4-VO), which induces DND in WKY rats, exhibited a severely decreased blood flow of\n13.7% of the preoperative value. DND was also observed in 4-week-old SHRSPs that\nunderwent 2-VO, and the incidence was identical to that in 12-week-old SHRSPs.\nThe present results suggest that the DND that occurs in SHRSPs due to 2-VO\nis not a result of the more severe reduction in blood supply during the occlusion than\nthat in WKY rats, and secondary damage due to severe hypertension but is caused by\nsome genetic factors due to which the pyramidal neurons of SHRSPs are more\nvulnerable to ischemic insult than those of WKY rats are.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Brain Research, 1229, pp.204-209; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.brainres.2008.06.105","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2008 Elsevier B.V. All rights reserved"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA0057324X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00068993","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinugawa, Hidekazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai-Yamashita, Yasuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niwa, Masami"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"BraRes1229_204.pdf","filesize":[{"value":"455.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BraRes1229_204.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18217/files/BraRes1229_204.pdf"},"version_id":"dda438c9-55e4-4bc7-95ad-57d9aa3a3891"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ischemia","subitem_subject_scheme":"Other"},{"subitem_subject":"neuronal death","subitem_subject_scheme":"Other"},{"subitem_subject":"hippocampus","subitem_subject_scheme":"Other"},{"subitem_subject":"SHRSP","subitem_subject_scheme":"Other"},{"subitem_subject":"blood flow","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-01"},"publish_date":"2008-09-01","publish_status":"0","recid":"18217","relation_version_is_last":true,"title":["Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:04:53.872054+00:00"}