{"created":"2023-05-15T16:43:01.999871+00:00","id":18219,"links":{},"metadata":{"_buckets":{"deposit":"23969e36-2bce-4eaf-93cd-aaadd3241009"},"_deposit":{"created_by":2,"id":"18219","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18219"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018219","sets":["10:11"]},"author_link":["72630","72635","72628","72631","72629","72632","72634","72633"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"217","bibliographicPageStart":"209","bibliographicVolumeNumber":"81","bibliographic_titles":[{"bibliographic_title":"European Journal of Haematology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Foxp3 is a master gene of Treg cells, a novel subset of CD4+ T cells primarily expressing CD25. We describe here different features in Foxp3 expression profile between normal and leukemic CD4+CD25+ T cells, using peripheral blood samples from healthy controls (HCs), human T-cell leukemia virus type-1 (HTLV-1)-infected asymptomatic carriers (ACs), patients with adult T-cell leukemia (ATL), and various hematopoietic cell lines. The majority of CD4+CD25+ T cells in HCs were positive for Foxp3, but not all CD4+CD25+ T cells in ACs were positive, indicating that Foxp3 expression is not always linked to CD25 expression in normal T cells. Leukemic (ATL) T cells constitutively expressing CD25 were characteristic of heterogeneous Foxp3 expression, such as intra- and inter-case heterogeneity in intensity, inconsistency with CD25 expression, and a discrepancy in the mRNA and its protein expression. Surprisingly, a discernible amount of Foxp3 mRNA was detectable even in most cell lines without CD25 expression, a small fraction of which was positive for the Foxp3 proteins. The subcellular localization of Foxp3 in HTLV-1-infected cell lines was mainly cytoplasmic, different from that of primary ATL cells. These findings indicate that Foxp3 has two facets: essential Treg identity and molecular mimicry secondary to tumorigenesis. Conclusively, Foxp3 in normal T cells, but not mRNA, is basically potent at discriminating a subset of Treg cells from CD25 + T-cell populations, whereas the modulation of Foxp3 expression in leukemic T cells could be implicated in oncogenesis and has a potentially useful clinical role.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"European Journal of Haematology, 81(3) pp.209-217; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Blackwell Publishing Inc."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1600-0609.2008.01105.x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2008 Blackwell Munksgaard"},{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10668976","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09024441","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abe, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchihashi, Kinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruda, Kazuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osaka, Akemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Hiroo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Yasuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamihira, Shimeru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"EJH81_209.pdf","filesize":[{"value":"654.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EJH81_209.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18219/files/EJH81_209.pdf"},"version_id":"27a3a3ab-18a9-4cfe-8a70-e1d71984cd66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult T-cell leukemia","subitem_subject_scheme":"Other"},{"subitem_subject":"CD25","subitem_subject_scheme":"Other"},{"subitem_subject":"Foxp3","subitem_subject_scheme":"Other"},{"subitem_subject":"Human T-cell leukemia virus type-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Treg","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-07"},"publish_date":"2009-10-07","publish_status":"0","recid":"18219","relation_version_is_last":true,"title":["Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:04:46.257804+00:00"}