{"created":"2023-05-15T16:43:02.131928+00:00","id":18222,"links":{},"metadata":{"_buckets":{"deposit":"0f81a0cc-03a1-409f-9480-bb6ada7b5c9d"},"_deposit":{"created_by":2,"id":"18222","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18222"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018222","sets":["8:9"]},"author_link":["72652","72650","72648","72646","72645","72647","72649","72653","72651"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1595","bibliographicPageStart":"1590","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have constructed a new ocular pharmacokinetic pharmacodynamic (PK/PD) model for anti-glaucoma\ndrugs to describe ocular hypotensive effects on intraocular pressure (IOP) after instillation of a combination of\nan a1-adrenergic antagonist, bunazosin, and a b -adrenergic antagonist, timolol, into rabbits. This model was\nconstructed by the combination of two ocular PK/PD models for bunazosin and timolol by including aqueous\nhumor dynamics based on both action mechanisms. We also verified the reliability of this model by confirming\nthe drug concentrations in aqueous humor and ocular hypotensive effects after instillation of the drug combination.\nThe aqueous humor concentrations of timolol and bunazosin were determined by an HPLC, and ocular hypotensive\neffect-time profiles were measured using a telemetry system, which was able to record automatically\ndetailed effects. The combined model could simulate the aqueous humor concentrations of both drugs and the\nadditive IOP-lowering effect after instillation of the combination using the MULTI (RUNGE) program and\nPK/PD parameters which were obtained from ocular hypotensive effects after instillation of bunazosin alone or\ntimolol alone. The theoretical concentration curves of both drugs in the aqueous humor and the theoretical ocular\nhypotensive effect curves almost agreed with both the observed concentrations and ocular hypotensive effects\nafter instillation of the drug combination. These results indicate the reliability and usefulness of PK/PD modeling\nconsidering aqueous humor dynamics to predict IOP in multidrug therapy. This is the first study to develop a\nPK/PD model for multidrug therapy for the eye.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological and Pharmaceutical Bulletin, 31(8), pp.1590-1595; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.31.1590","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2008 The Pharmaceutical Society of Japan"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09186158","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5215","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakanaka, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawazu, Kouichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomonari, Masahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitahara, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Mikiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Koyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Junzo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi, Shun"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"BPB31_1590.pdf","filesize":[{"value":"195.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BPB31_1590.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18222/files/BPB31_1590.pdf"},"version_id":"b9faf5f4-b547-43b7-aba0-313423686382"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"timolol","subitem_subject_scheme":"Other"},{"subitem_subject":"bunazosin","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacodynamics","subitem_subject_scheme":"Other"},{"subitem_subject":"aqueous humor dynamics","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs"}]},"item_type_id":"2","owner":"2","path":["9"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-02"},"publish_date":"2008-09-02","publish_status":"0","recid":"18222","relation_version_is_last":true,"title":["Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:04:38.416501+00:00"}