@article{oai:nagasaki-u.repo.nii.ac.jp:00018233,
 author = {Kawasaki, Eiji and Imagawa, Akihisa and Makino, Hideichi and Uga, Miho and Abiru, Norio and Hanafusa, Toshiaki and Uchigata, Yasuko and Eguchi, Katsumi},
 issue = {8},
 journal = {Diabetes care},
 month = {Aug},
 note = {OBJECTIVE: To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes. RESEARCH DESIGN AND METHODS: We genotyped the +49G>A and CT60G>A variants of the CTLA4 gene in fulminant type 1 diabetic patients (n = 55), classic type 1A diabetic patients (n = 91), and healthy control subjects (n = 369). We also assessed serum levels of the soluble form of CTLA4 (sCTLA4). RESULTS: The +49GG and CT60GG genotypes were associated with type 1A diabetes (P < 0.001). In contrast, the CT60AA genotype, but not the +49G>A variation, was associated with fulminant type 1 diabetes (P < 0.05), especially in patients carrying HLA-DR4 (P < 0.01). Serum levels of sCTLA4 were significantly decreased in patients with fulminant type 1 diabetes (P < 0.05). CONCLUSIONS: These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes. Furthermore, the contribution of CTLA4 to disease susceptibility is distinct between fulminant type 1 diabetes and classic type 1A diabetes., Diabetes Care, 31(8), pp.1608-1610; 2008},
 pages = {1608--1610},
 title = {Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients.},
 volume = {31},
 year = {2008}
}