@article{oai:nagasaki-u.repo.nii.ac.jp:00018244,
 author = {Yamaguchi, M. and Ukai, Takashi and Kaneko, T. and Yoshinaga, Megumi and Yokoyama, M. and Ozaki, Y. and Hara, Yoshitaka},
 issue = {5},
 journal = {Journal of periodontal research},
 month = {Oct},
 note = {Background and Objective: T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption in the absence of B cells. In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID). Material and Methods: Escherichia coli lipopolysaccharide (LPS) was injected into the gingivae of SCID mice reconstituted by T cells (SCID + T mice). Wild-type C.B-17 mice and SCID mice were used as control animals. Alveolar bone resorption and production of cytokines in the gingivae were then compared histopathologically and immunohistologically. Results: The degree of bone resorption in SCID + T mice was significantly greater than that in SCID mice but less than that in wild-type mice. The same tendency was found for expression of receptor activator of nuclear factor kappaB ligand. The number of interferon-gamma-positive cells in SCID + T mice was the highest of the three groups. In contrast, interleukin-4-positive cells were detected in wild-type mice but not in SCID + T and SCID mice. Conclusion: The results suggest that T cells are able to promote LPS-induced bone resorption in the absence of B cells. The expressions of cytokines in the presence of B cells are quite different., Journal of Periodontal Research, 43(5), pp.549-555; 2008},
 pages = {549--555},
 title = {T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.},
 volume = {43},
 year = {2008}
}