{"created":"2023-05-15T16:43:03.081685+00:00","id":18244,"links":{},"metadata":{"_buckets":{"deposit":"931dc78f-2149-465e-914a-abf6f00ed59d"},"_deposit":{"created_by":2,"id":"18244","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18244"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018244","sets":["27:28"]},"author_link":["72804","72801","72800","72805","72806","72802","72803"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"555","bibliographicPageStart":"549","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Journal of periodontal research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Objective: T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption in the absence of B cells. In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID). Material and Methods: Escherichia coli lipopolysaccharide (LPS) was injected into the gingivae of SCID mice reconstituted by T cells (SCID + T mice). Wild-type C.B-17 mice and SCID mice were used as control animals. Alveolar bone resorption and production of cytokines in the gingivae were then compared histopathologically and immunohistologically. Results: The degree of bone resorption in SCID + T mice was significantly greater than that in SCID mice but less than that in wild-type mice. The same tendency was found for expression of receptor activator of nuclear factor kappaB ligand. The number of interferon-gamma-positive cells in SCID + T mice was the highest of the three groups. In contrast, interleukin-4-positive cells were detected in wild-type mice but not in SCID + T and SCID mice. Conclusion: The results suggest that T cells are able to promote LPS-induced bone resorption in the absence of B cells. The expressions of cytokines in the presence of B cells are quite different.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Periodontal Research, 43(5), pp.549-555; 2008","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18624940","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1600-0765.2008.01083.x","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2008 Blackwell Munksgaard"},{"subitem_rights":"The definitive version is available at www.blackwell-synergy.com"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00704381","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16000765","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ukai, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, T."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshinaga, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ozaki, Y."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Yoshitaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JPR43_549.pdf","filesize":[{"value":"855.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JPR43_549.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18244/files/JPR43_549.pdf"},"version_id":"19aac268-3ea6-4b6d-8894-d3810133c788"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone resorption","subitem_subject_scheme":"Other"},{"subitem_subject":"RANKL","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharide","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells."}]},"item_type_id":"2","owner":"2","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-11-04"},"publish_date":"2009-11-04","publish_status":"0","recid":"18244","relation_version_is_last":true,"title":["T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:03:44.547251+00:00"}