{"created":"2023-05-15T16:43:04.410258+00:00","id":18275,"links":{},"metadata":{"_buckets":{"deposit":"fa734c9f-7b46-4200-af87-24f1e546684d"},"_deposit":{"created_by":2,"id":"18275","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18275"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018275","sets":["25:26"]},"author_link":["72965","72961","72963","72964","72962"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"769","bibliographicPageStart":"761","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"International journal of radiation biology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. Materials and methods: Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB/c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated. Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2(h4) mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB/c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells. Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2(h4) mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Journal of Radiation Biology, 84(9), pp.761-769; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18821390","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/09553000802345910","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an electronic version of an article published in International Journal of Radiation Biology, 2008, 84(9), p.761-769. International Journal of Radiation Biology is available online at: http://www.informaworld.com/openurl?genre=article&doi:10.1080/09553000802345910"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10686424","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09553002","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_8":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1362-3095","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagayama, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaminoda, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizutori, Yumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saitoh, Ohki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abiru, Norio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"IJRB84_761.pdf","filesize":[{"value":"477.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJRB84_761.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18275/files/IJRB84_761.pdf"},"version_id":"2ec89c06-e4e2-470c-be89-0998c51571ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adenovirus","subitem_subject_scheme":"Other"},{"subitem_subject":"Iodide","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroglobulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroid autoimmunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyrotropin receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2(h4) mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2(h4) mice."}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-07"},"publish_date":"2009-10-07","publish_status":"0","recid":"18275","relation_version_is_last":true,"title":["Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2(h4) mice."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:02:35.489169+00:00"}