@article{oai:nagasaki-u.repo.nii.ac.jp:00018306,
 author = {Huaman, Maria Cecilia and Roncal, Norma and Nakazawa, Shusuke and Long, Ton That Ai and Gerena, Lucia and Garcia, Coralith and Solari, Lely and Magill, Alan J. and Kanbara, Hiroji},
 issue = {5},
 journal = {American Journal of Tropical Medicine and Hygiene},
 month = {May},
 note = {In vitro drug sensitivity to chloroquine (CQ), mefloquine (MQ) and quinine was investigated in 60 culture-adapted Plasmodium falciparum isolates from malaria patients in Padrecocha, a village in the Amazonian Department of Loreto, Peru. All isolates showed resistance to CQ, decreased susceptibility to quinine, and sensitivity to MQ. These isolates were examined for mutations in the P. falciparum multidrug resistance 1 (pfmdr1) and chloroquine resistance transporter (pfcrt) genes previously linked to CQ resistance. The mutations N86Y and D1246Y, two of the five mutations commonly observed in the pfmdr1 gene of CQ-resistant clones, were not found. The pfcrt mutation K76T, associated with CQ resistance, was identified in all the isolates tested. Sequence analysis of codons 72-76 in the pfcrt gene showed the haplotypes SVMNT and CVMNT., American Journal of Tropical Medicine and Hygiene, 70(5), pp.461-466; 2004},
 pages = {461--466},
 title = {Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.},
 volume = {70},
 year = {2004}
}