{"created":"2023-05-15T16:43:05.761974+00:00","id":18306,"links":{},"metadata":{"_buckets":{"deposit":"34951b3e-48b8-4d59-ad43-a3bd6c0e7971"},"_deposit":{"created_by":2,"id":"18306","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18306"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018306","sets":["35:36"]},"author_link":["73133","73132","73134","73137","73136","73130","73129","73135","73131"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"466","bibliographicPageStart":"461","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"American Journal of Tropical Medicine and Hygiene"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In vitro drug sensitivity to chloroquine (CQ), mefloquine (MQ) and quinine was investigated in 60 culture-adapted Plasmodium falciparum isolates from malaria patients in Padrecocha, a village in the Amazonian Department of Loreto, Peru. All isolates showed resistance to CQ, decreased susceptibility to quinine, and sensitivity to MQ. These isolates were examined for mutations in the P. falciparum multidrug resistance 1 (pfmdr1) and chloroquine resistance transporter (pfcrt) genes previously linked to CQ resistance. The mutations N86Y and D1246Y, two of the five mutations commonly observed in the pfmdr1 gene of CQ-resistant clones, were not found. The pfcrt mutation K76T, associated with CQ resistance, was identified in all the isolates tested. Sequence analysis of codons 72-76 in the pfcrt gene showed the haplotypes SVMNT and CVMNT.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"American Journal of Tropical Medicine and Hygiene, 70(5), pp.461-466; 2004","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society of Tropical Medicine and Hygiene"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"15155976","subitem_relation_type_select":"PMID"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.ajtmh.org/cgi/content/abstract/70/5/461"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2004 by The American Society of Tropical Medicine and Hygiene"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00521439","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00029637","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Huaman, Maria Cecilia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Roncal, Norma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakazawa, Shusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Long, Ton That Ai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gerena, Lucia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Garcia, Coralith"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Solari, Lely"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Magill, Alan J."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanbara, Hiroji"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"ajtmh70_461.pdf","filesize":[{"value":"105.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ajtmh70_461.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18306/files/ajtmh70_461.pdf"},"version_id":"a6fb6f54-cfdd-481e-8ef4-17da310ea396"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon."}]},"item_type_id":"2","owner":"2","path":["36"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-21"},"publish_date":"2008-10-21","publish_status":"0","recid":"18306","relation_version_is_last":true,"title":["Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T04:01:18.259746+00:00"}