@article{oai:nagasaki-u.repo.nii.ac.jp:00018976,
 author = {Hirakawa, Hiroshi and Nakayama, Toshiyuki and Shibata, Kenichiro and Mihara, Yumi and Taba, Mitsuru and Nagayasu, Takeshi and Sekine, Ichiro},
 issue = {1},
 journal = {Cancer letters},
 month = {Mar},
 note = {Glycogen synthase kinase 3beta (GSK-3beta) was subsequently shown to function in a wide range of cellular processes. GSK-3beta is a multifunctional serine/threonine kinase which performs a role in several signaling pathways including Wnt signal transduction. Recently, the activity of membrane-localized GSK-3beta has been shown to be crucial for initiation of Wnt cascade. In our study, the membrane localization of GSK-3beta was found on the apical membrane of normal epithelium, where co-localized and directly bound with MUC1. In colorectal cancer, depolarized cells showed the aberrant distribution of GSK-3beta on the cellular membrane with beta-catenin nuclear accumulation. The aberrant distribution of the membrane-localized GSK-3beta may contribute to the development of colorectal cancer., Cancer Letters, 275(1), pp.158-162; 2009},
 pages = {158--162},
 title = {Apical membrane localization of glycogen synthase kinase 3beta protein in normal colon epithelium and aberrant distribution in colorectal cancer.},
 volume = {275},
 year = {2009}
}