@article{oai:nagasaki-u.repo.nii.ac.jp:00018989,
 author = {鈴木, 啓司 and 児玉, 靖司 and 渡邉, 正己},
 issue = {2},
 journal = {環境変異原研究, Environmental mutagen research communication},
 month = {Jul},
 note = {Ionizing radiation induces genomic instability, which is transmitted through many generations after irradiation in the progeny of surviving cells. We have hypothesized that radiation-induced large deletion causes potentially unstable chromosome regions, which are involved in delayed induction of radiation-induced genomic instability. Using phosphorylation-specific antibodies against ATM and histone H2AX, whose phosphorylation is induced by DNA double strand breaks, we detected delayed induction of phosphorylated ATM and H2AX foci in the progeny of X-ray-surviving cells, which indicated delayed induction of DNA double strand breaks. Furthermore, we found delayed chromosomal instability in X chromosomes in clones which contain large deletion involving the HPRT loci. It is suggested that large deletion involving ～Mb region causes unstable chromatin structure, and it results in delayed rearrangement of chromosomes involved. These findings provide the possibility that manifestation of radiation-induced genomic instability results from delayed DNA breaks, i.e., the breaks lead to delayed chromosome rearrangements, delayed cell death etc., many generations after irradiation., 環境変異原研究, 27(2), pp. 111-115; 2005},
 pages = {111--115},
 title = {遅延性DNA損傷の誘発と遺伝的不安定性},
 volume = {27},
 year = {2005}
}