{"created":"2023-05-15T16:43:35.468768+00:00","id":18989,"links":{},"metadata":{"_buckets":{"deposit":"9d08c509-4379-492d-a1fa-349b07f4932e"},"_deposit":{"created_by":2,"id":"18989","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"18989"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00018989","sets":["25:26"]},"author_link":["77930","77929","77925","77927","77928","77926"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Delayed DNA damage and radiation-induced genomic instability"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"115","bibliographicPageStart":"111","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"環境変異原研究"},{"bibliographic_title":"Environmental mutagen research communication","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ionizing radiation induces genomic instability, which is transmitted through many generations after irradiation in the progeny of surviving cells. We have hypothesized that radiation-induced large deletion causes potentially unstable chromosome regions, which are involved in delayed induction of radiation-induced genomic instability. Using phosphorylation-specific antibodies against ATM and histone H2AX, whose phosphorylation is induced by DNA double strand breaks, we detected delayed induction of phosphorylated ATM and H2AX foci in the progeny of X-ray-surviving cells, which indicated delayed induction of DNA double strand breaks. Furthermore, we found delayed chromosomal instability in X chromosomes in clones which contain large deletion involving the HPRT loci. It is suggested that large deletion involving ～Mb region causes unstable chromatin structure, and it results in delayed rearrangement of chromosomes involved. These findings provide the possibility that manifestation of radiation-induced genomic instability results from delayed DNA breaks, i.e., the breaks lead to delayed chromosome rearrangements, delayed cell death etc., many generations after irradiation.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"環境変異原研究, 27(2), pp. 111-115; 2005","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"77928","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suzuki, Keiji"}]},{"nameIdentifiers":[{"nameIdentifier":"77929","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kodama, Seiji"}]},{"nameIdentifiers":[{"nameIdentifier":"77930","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Masami"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本環境変異原学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本環境変異原学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN1006217X","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09100865","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 啓司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"児玉, 靖司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡邉, 正己"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"110001789612.pdf","filesize":[{"value":"629.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110001789612.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/18989/files/110001789612.pdf"},"version_id":"0a66a9d6-11b5-4019-9887-a6dc025c3569"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"genome","subitem_subject_scheme":"Other"},{"subitem_subject":"instability","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA damage","subitem_subject_scheme":"Other"},{"subitem_subject":"chromatin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"遅延性DNA損傷の誘発と遺伝的不安定性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遅延性DNA損傷の誘発と遺伝的不安定性"}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-15"},"publish_date":"2008-12-15","publish_status":"0","recid":"18989","relation_version_is_last":true,"title":["遅延性DNA損傷の誘発と遺伝的不安定性"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:36:04.305146+00:00"}