@article{oai:nagasaki-u.repo.nii.ac.jp:00019027,
 author = {Honma, Kiri and Kimura, Daisuke and Tominaga, Norio and Miyakoda, Mana and Matsuyama, Toshifumi and Yui, Katsuyuki},
 issue = {41},
 journal = {Proceedings of the National Academy of Sciences of the United States of America},
 month = {Oct},
 note = {Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using IRF-4(-/-) BALB/c mice. However, naive IRF-4(-/-)CD4(+) T cells produced Th2 cytokines, including IL-4, IL-5, and IL-10, but not IL-2 or IFN-gamma, at levels higher than wild-type BALB/c CD4(+) T cells in response to T cell receptor stimulation. In contrast, effector/memory IRF-4(-/-)CD4(+) T cells did not exhibit increased production of Th2 cytokines. Knockdown of IRF-4 expression by using small interfering RNA promoted IL-4 production in naive CD4(+) T cells but inhibited it in effector/memory CD4(+) T cells. These results indicate that IRF-4 plays differential roles in the regulation of Th2 cytokine production in naive CD4(+) T cells and effector/memory CD4(+) T cells. IRF-4 inhibits Th2 cytokine production in naive CD4(+) T cells, whereas it promotes Th2 cytokine production in effector/memory CD4(+) T cells., Proceedings of the National Academy of Sciences of the United States of America, 105(41), pp.15890-15895; 2008},
 pages = {15890--15895},
 title = {Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells.},
 volume = {105},
 year = {2008}
}