{"created":"2023-05-15T16:43:37.133470+00:00","id":19028,"links":{},"metadata":{"_buckets":{"deposit":"141d69b9-5681-41b2-8a12-7e1df713b715"},"_deposit":{"created_by":2,"id":"19028","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19028"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019028","sets":["50:51"]},"author_link":["78136","78132","78138","78139","78134","78135","78133","78137"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"103","bibliographicPageStart":"99","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Toxicon : official journal of the International Society on Toxinology"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tetrodotoxin (TTX) was intramuscularly administered to non-toxic cultured specimens of the pufferfish Takifugu rubripes to investigate TTX transfer/accumulation profiles in the pufferfish body. In two groups of test fish administered either 50MU/individual of TTX standard (purified TTX; PTTX) or crude extract of toxic pufferfish ovary (crude TTX; CTTX), TTX rapidly transferred from the muscle via the blood to other organs. The toxin transfer profiles differed between groups, however, from 4 to 72h. In the PTTX group, little TTX was retained in the liver, and most (>96%) of the toxin remaining in the body transferred/accumulated in the skin after 12h, whereas in the CTTX group, a considerable amount of toxin (15%-23% of the administered toxin or 28%-58% of the remaining toxin) was transferred/retained in the liver for up to 24h, despite the fact that 89% of the remaining toxin transferred/accumulated in the skin at the end of rearing period (168h). The total amount of toxin remaining in the entire body at 1-4h was approximately 60% of the administered toxin in both groups, which decreased at 8-12h, and then increased again to approximately 60%-80% at 24-168h. Immunohistochemical observation revealed that the toxin accumulated in the skin was localized at the basal cells of the epidermal layer.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Toxicon : official journal of the International Society on Toxinology, 53(1), pp.99-103; 2009","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18996407","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.toxicon.2008.10.018","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"www.elsevier.com/locate/toxicon"}]}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright c 2008 Elsevier Ltd All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11540151","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00410101","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Emoto, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ngy, Laymithuna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniyama, Shigeto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagi, Motoaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatani, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arakawa, Osamu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"Toxicon53_99.pdf","filesize":[{"value":"262.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Toxicon53_99.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19028/files/Toxicon53_99.pdf"},"version_id":"c57a3e63-8dce-4212-a2b1-25b7ef400bc8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tetrodotoxin","subitem_subject_scheme":"Other"},{"subitem_subject":"Pufferfish","subitem_subject_scheme":"Other"},{"subitem_subject":"Takifugu rubripes","subitem_subject_scheme":"Other"},{"subitem_subject":"Intramuscular administration","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemical observation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes."}]},"item_type_id":"2","owner":"2","path":["51"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-21"},"publish_date":"2009-01-21","publish_status":"0","recid":"19028","relation_version_is_last":true,"title":["Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:34:30.018661+00:00"}