{"created":"2023-05-15T16:43:37.175714+00:00","id":19029,"links":{},"metadata":{"_buckets":{"deposit":"67f2f9ad-db7f-420d-9345-67b0f4666bb8"},"_deposit":{"created_by":2,"id":"19029","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19029"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019029","sets":["25:26"]},"author_link":["78147","78143","78140","78141","78144","78145","78148","78146","78142","78149"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11-12","bibliographicPageEnd":"965","bibliographicPageStart":"957","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Free radical research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dehydroepiandrosterone (DHEA) modulates sensitivity to radiation-induced injury in human neuroglioma cells (H4) through effects on Akt signalling by glutathione (GSH)-dependent redox regulation. Previous treatment of H4 cells with DHEA for 18 h reduced the gamma-ray-induced phosphorylation of Akt, activated p21(waf1) synthesis and up-regulated phosphorylation of Rb independent of p53. These reactions were followed by a decrease in cell number and an increase in apoptosis and G(2)/M checkpoint arrest. The suppression of phosphorylation of Akt by DHEA was due to regulation of the dephosphorylation by protein phosphatase 2A (PP2A). DHEA up-regulated the expression of gamma-glutamylcysteine synthetase, a rate-limiting enzyme of glutathione (GSH) synthesis, and the levels of GSH to maintain PP2A activity. The results suggested that DHEA increases the sensitivity of cells to gamma-ray irradiation by inducing apoptosis and cell cycle arrest through GSH-dependent regulation of the reduced form of PP2A to down-regulate the Akt signalling pathway.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Free Radical Research, 42(11-12), pp.957-965; 2008","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"19031317","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/10715760802566582","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2008 Informa plc"},{"subitem_rights":"This is an electronic version of an article published in Free Radical Research, 42(11-12), 957-965: 2008 November. Free Radical Research is available online at: http://www.informaworld.com/openurl?genre=article&issn=10715762&volume=42&issue=11&spage=957"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10715762","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirao, Tomohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Urata, Yoshishige"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kageyama, Kan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikezaki, Midori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakatsu, Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuse, Michiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuo, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akishita, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Izumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kondo, Takahito"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"FRR42_957.pdf","filesize":[{"value":"647.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FRR42_957.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19029/files/FRR42_957.pdf"},"version_id":"b788bc7e-d3f1-4265-a220-b2c4d8ba992e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dehydroepiandrosterone","subitem_subject_scheme":"Other"},{"subitem_subject":"radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Akt","subitem_subject_scheme":"Other"},{"subitem_subject":"protein phosphatase 2A","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling."}]},"item_type_id":"2","owner":"2","path":["26"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-03"},"publish_date":"2009-12-03","publish_status":"0","recid":"19029","relation_version_is_last":true,"title":["Dehydroepiandrosterone augments sensitivity to gamma-ray irradiation in human H4 neuroglioma cells through down-regulation of Akt signaling."],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:34:24.146348+00:00"}