@article{oai:nagasaki-u.repo.nii.ac.jp:00001916,
 author = {Shimizu, Yuji and Yamanashi, Hirotomo and Noguchi, Yuko and Koyamatsu, Jun and Nagayoshi, Mako and Kiyoura, Kairi and Fukui, Shoichi and Tamai, Mami and Kawashiri, Shin-Ya and Arima, Kazuhiko and Maeda, Takahiro},
 issue = {1},
 journal = {Environmental Health and Preventive Medicine},
 month = {May},
 note = {Background: Hypertension and atherosclerosis are bidirectionally related, while platelet count could serve as an indicator of endothelial repair. Therefore, high platelet counts could be associated with hypertension by indicating more intense endothelial 
repair activity. Furthermore, short stature has been shown to constitute a risk of atherosclerosis. Since inflammation-related single-nucleotide polymorphism (SNP(rs3782886)) is reportedly associated
 with myocardial infarction and short stature, rs3782886 could be associated 
with a high platelet count and thus more intense endothelial repair activity. 
Methods: We conducted a cross-sectional study of 988 elderly Japanese who participated in a general health check-up. Short stature was defined as a height of at or under the 25th percentile of the study population, and high platelet count as the highest tertiles of the platelet levels. Results: High platelet counts were found to be independently and positively associated with hypertension while rs3782886 was independently associated with high platelet levels and short stature. The classical cardiovascular risk factor-adjusted odds ratio (OR) and 95% confidence interval (CI) of high platelet count for hypertension was 1.34 (1.02, 1.77). With non-minor homo of the rs3782886 as the reference group, the adjusted OR and 95% CI for high platelet count and short stature of minor home were 2.40 (1.30, 4.42) and 2.21 (1.16, 4.21), 
respectively. Conclusion: SNP (rs3782886) was shown to be associated with high platelet count and short stature. This result partly explains how a genetic factor can influence the impact of height on endothelial repair., Environmental Health and Preventive Medicine, 24(1), art.no.26; 2019},
 title = {Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese},
 volume = {24},
 year = {2019}
}