@article{oai:nagasaki-u.repo.nii.ac.jp:00019366, author = {Onomura, Osamu and Kirira, Peter G and Tanaka, Toshimitsu and Tsukada, Shinsuke and Matsumura, Yoshihiro and Demizu, Yosuke}, issue = {32}, journal = {Tetrahedron}, month = {Aug}, note = {Diastereoselective introduction of nucleophiles into L-proline derivatives at the 5-position was achieved with suitable selection of N-protecting group. N-Methoxycarbonylated or benzyloxycarbonylated L-proline derivatives reacted with arene to give cis-arylated products. On the other hand, N-benzoylated L-proline derivative preferentially gave trans-arylated product which could be easily transformed into optically active C2-symmetrical pyrrolidine derivative. Such derivative 5, worked well as an organic activator in the asymmetric reduction of aromatic imines by Cl3SiH., Tetrahedron, 64(32), pp.7498-7503; 2008}, pages = {7498--7503}, title = {Diastereoselective arylation of l-proline derivatives at the 5-position}, volume = {64}, year = {2008} }