{"created":"2023-05-15T16:43:52.081518+00:00","id":19372,"links":{},"metadata":{"_buckets":{"deposit":"acd7628e-9aae-417c-a169-2e2928bd7ca6"},"_deposit":{"created_by":2,"id":"19372","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19372"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019372","sets":["29:30"]},"author_link":["80668","80671","80670","80677","80674","80676","80678","80675","80672","80669","80673"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"54","bibliographicPageStart":"47","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Journal of Dermatological Science"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. Objective: To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. Methods: Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collagenase activity was determined using biotinylated collagen as substrate and the amount of cleaved biotinylated fragments of collagen by MMP-1 was measured by ELISA. Results: LSc patients exhibited significantly elevated IgG anti-MMP-1 Ab levels relative to normal controls at similar level of patients with systemic sclerosis (SSc). However, IgG anti-MMP-1 Ab levels were comparable among the 3 LSc subgroups: morphea, linear scleroderma, and generalized morphea. When absorbance values higher than the mean + 2S.D. of normal controls were considered positive, IgG or IgM anti-MMP-1 Ab was found in 46% and 49% of total LSc patients and SSc patients, respectively. Anti-MMP-1 Ab was detected most frequently in morphea patients (60%), followed by linear scleroderma patients (47%) and then generalized morphea patients (25%). LSc patients positive for IgG anti-MMP-1 Ab had elevated levels of IgG anti-single-stranded DNA Ab, IgG anti-nucleosome Ab, and shorter disease duration relative to those negative. The presence of anti-MMP-1 Ab in LSc patients was confirmed by immunoblotting. IgG isolated from LSc patients' sera positive for IgG anti-MMP-1 Ab by ELISA inhibited MMP-1 collagenase activity. Conclusion: These results suggest that anti-MMP-1 autoantibody is a novel autoantibody in LSc. c 2008 Japanese Society for Investigative Dermatology.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of Dermatological Science, 52(1), pp.47-54; 2008","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"18565735","subitem_relation_type_select":"PMID"}}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jdermsci.2008.04.013","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 Elsevier Inc. All rights reserved."}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11531842","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09231811","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomimura, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Fumihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Toshihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muroi, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Motoi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Minoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujimoto, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Shinichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"JDS52_47.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JDS52_47.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19372/files/JDS52_47.pdf"},"version_id":"a91f3302-411e-4377-9b46-430081eadb8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Localized scleroderma","subitem_subject_scheme":"Other"},{"subitem_subject":"Matrix metalloproteinase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Autoantibody","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-07-11"},"publish_date":"2008-07-11","publish_status":"0","recid":"19372","relation_version_is_last":true,"title":["Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:20:17.871630+00:00"}