@article{oai:nagasaki-u.repo.nii.ac.jp:00019479,
 author = {Matsuu-Matsuyama, Mutsumi and Shichijo, Kazuko and Okaichi, Kumio and Ishii, Kouji and Wen, Chung Yang and Fukuda, Eiichiro and Nakayama, Toshiyuki and Nakashima, Masahiro and Okumura, Yutaka and Sekine, Ichiro},
 issue = {1},
 journal = {Journal of radiation research},
 month = {Mar},
 note = {Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following: (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region., Journal of radiation research. 2006, 47(1), p.1-8},
 pages = {1--8},
 title = {Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats},
 volume = {47},
 year = {2006}
}