{"created":"2023-05-15T16:43:56.718616+00:00","id":19479,"links":{},"metadata":{"_buckets":{"deposit":"4ee3a6d5-1552-4da1-aa39-0d10942a1005"},"_deposit":{"created_by":2,"id":"19479","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19479"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019479","sets":["29:30"]},"author_link":["81321","81318","81326","81327","81324","81322","81323","81325","81320","81319"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiotherapy for malignant pelvic disease is often followed by acute radiation colitis (ARC). It has been reported that sucralfate treatment has a protective effect against ARC, though the mechanisms of action are unknown. The effects of sucralfate on X-ray radiation-induced apoptosis was studied at 4 Gy in the colonic crypt cells of rats. Sucralfate enemas given prior to radiation resulted in the following: (1) reduction in number of apoptotic colonic crypt cells; (2) reduction in number of caspase-3 positive cells; (3) decreases in p53 accumulation and p21 expression; (4) decreases of Bax/Bcl-2 ratio. The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 2006, 47(1), p.1-8","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuu-Matsuyama, Mutsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shichijo, Kazuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okaichi, Kumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Kouji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wen, Chung Yang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Eiichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakashima, Masahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sekine, Ichiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR47_1_1_8.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR47_1_1_8.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19479/files/RR47_1_1_8.pdf"},"version_id":"404db5f1-6e18-4ab9-a716-8e175a33cc27"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Radiation-induced apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Sucralfate","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"},{"subitem_subject":"Rats","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-11"},"publish_date":"2008-08-11","publish_status":"0","recid":"19479","relation_version_is_last":true,"title":["Sucralfate Protects Intestinal Epithelial Cells from Radiation-Induced Apoptosis in Rats"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:16:06.123947+00:00"}