@article{oai:nagasaki-u.repo.nii.ac.jp:00019484,
 author = {Okaichi, Kumio and Usui, Aya and Ohnishi, Takeo and Okumura, Yutaka},
 issue = {Supplement},
 journal = {Journal of radiation research},
 month = {Dec},
 note = {To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 × g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 × g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells., Journal of radiation research. 2002, 43(Supplement), p.261-264},
 pages = {261--264},
 title = {Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53},
 volume = {43},
 year = {2002}
}