{"created":"2023-05-15T16:43:56.935338+00:00","id":19484,"links":{},"metadata":{"_buckets":{"deposit":"f36292cd-4be5-489b-8b3b-c371fe592d58"},"_deposit":{"created_by":2,"id":"19484","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19484"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019484","sets":["29:30"]},"author_link":["81353","81351","81352","81350"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"264","bibliographicPageStart":"261","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 × g) induced the accumulation of p53 in the human glioblastoma cell line A172 after 3 h of incubation. Low-dose (0.5 Gy) irradiation to the cells accumulated p53 1.5 h after irradiation, and induced Waf-1 and Bax. Under the condition of hypergravity (20 × g), the peak of p53 accumulation was shifted from 1.5 h to 3 h after irradiation, and the inductions of Waf-1 and Bax were suppressed entirely. These results indicate that hypergravity modifies the signal transduction of ionizing radiation through p53 in the cells.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 2002, 43(Supplement), p.261-264","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okaichi, Kumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui, Aya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohnishi, Takeo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yutaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR43_S261_264.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR43_S261_264.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19484/files/RR43_S261_264.pdf"},"version_id":"fafaf9a4-9144-4593-8433-67ca7200df4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hypergravity","subitem_subject_scheme":"Other"},{"subitem_subject":"Ionizing radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal transduction","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-11"},"publish_date":"2008-08-11","publish_status":"0","recid":"19484","relation_version_is_last":true,"title":["Hypergravity Modifies the Signal Transduction of Ionizing Radiation through p53"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:15:53.254842+00:00"}