{"created":"2023-05-15T16:43:58.677674+00:00","id":19524,"links":{},"metadata":{"_buckets":{"deposit":"77221fc2-08a6-455f-8c20-72b0c1ae3058"},"_deposit":{"created_by":2,"id":"19524","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19524"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019524","sets":["29:30"]},"author_link":["81583","81584","81585","81582"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"118","bibliographicPageStart":"111","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have constructed an in vitro system to examine how p53 mutants affect radiosensitivity. Mutations of p53 were made using in vitro mutagenesis, and mutant cDNAs were introduced into the human osteosarcoma cell line, Saos-2, which is devoid of endogenous p53. For wild type p5 both the expression plasmid and a regulation plasmid (LacSwitch system) were transfected into the cells. The radiosensitivities of clones of mutant p53 and wild type p53 were examined. Transformants of wild type p53 had increased radiosensitivity. The induction of wild type p53 protein by addition of IPTG did not significantly increase radiosensitivity. A mutation at codon 123 also increased radiosensitivity. Mutations at codons 143, 175, and 273 did not alter radiosensitivity.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of radiation research. 1998, 39(2), p.111-118","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本放射線影響学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本放射線影響学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00705792","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"04493060","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okaichi, Kumio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Li-Hong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ihara, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yutaka"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"RR39_2_111_118.pdf","filesize":[{"value":"386.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"RR39_2_111_118.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19524/files/RR39_2_111_118.pdf"},"version_id":"3e8f15c3-885a-4165-9d3a-c6402f526b38"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ionizing radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"Mutant p53","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiosensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"Transformant","subitem_subject_scheme":"Other"},{"subitem_subject":"Saos-2 cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sensitivity to Ionizing Radiation in Saos-2 Cells Transfected with Mutant p53 Genes Depends on the Mutation Position","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sensitivity to Ionizing Radiation in Saos-2 Cells Transfected with Mutant p53 Genes Depends on the Mutation Position"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-11"},"publish_date":"2008-08-11","publish_status":"0","recid":"19524","relation_version_is_last":true,"title":["Sensitivity to Ionizing Radiation in Saos-2 Cells Transfected with Mutant p53 Genes Depends on the Mutation Position"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:14:11.143094+00:00"}