{"created":"2023-05-15T16:44:02.462165+00:00","id":19613,"links":{},"metadata":{"_buckets":{"deposit":"934f9b38-1c7c-4dc7-8673-cb313e498f3c"},"_deposit":{"created_by":2,"id":"19613","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"19613"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00019613","sets":["29:30"]},"author_link":["82101","82102","82106","82105","82103","82099","82104","82100"],"item_2_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Early In Vitro Detection of Interleukin-2-Like Activities by Pretreatment with Allogeneic Blood Lymphocytes in Miniature Swine"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-06-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"369","bibliographicPageStart":"365","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"The journal of veterinary medical science"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミニブタの同種移植における免疫反応の指標を得る目的で, ドナー末梢血リンパ球(PBL)前処置した後, ドナーPBLに対する in vitroでのIL-2様活性の測定を行い, 以下の結果が得られた: (1)MHC不適合無処置群の48時間MLC上清中にIL-2様活性がみられ, 48時間培養の方が高値であった; (2)MHC不適合PBLを1回移植した群は, 無処置群よりも in vitroでのIL-2様活性は高値であった; (3)MHC不適合PBLを週1回計4回移植した群は, in vitroでのIL-2様活性の検出がやや早期に認められた.","subitem_description_type":"Abstract"},{"subitem_description":"In order to determine the means of monitoring the immunological status of allograft recipients in miniature swine, an assay was developed to measure interleukin (IL)-2 production in vitro by pretreatment of donor peripheral blood lymphocytes (PBL). Miniature swine were given 0 to 4 weekly intravenous transfusions of 5-10×10^7 donor PBL incompatible at major histocompatibility complex (MHC) and assayed in vitro for donor specific immune IL-2-like activities. The results are summarized as follows: (1) IL-2-like activity in 24 hr and 48 hr supernatants from mixed lymphocyte cultures (MLC) with MHC-incompatible PBL was detected without pretreatment. The 48 hr MLC supernatant exhibited a high IL-2-like activity compared with the 24 hr; (2) IL-2-like activity after only one transfusion with MHC-incompatible PBL was higher than that without pretreatment; (3) IL-2-like activity in 4 weekly transfusions was detectable slightly earlier than that without pretreatment or three transfusions with MHC-incompatibile PBL.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"The journal of veterinary medical science. 1991, 53(3), p.365-369","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"82104","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Taura, Yasuho"}]},{"nameIdentifiers":[{"nameIdentifier":"82105","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsunoda, Tsukasa"}]},{"nameIdentifiers":[{"nameIdentifier":"82106","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shiogama, Toshiaki"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"社団法人日本獣医学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"社団法人日本獣医学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09167250","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田浦, 保穂"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"角田, 司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"塩竃, 利昭"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mullen, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Papoian, Tom"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-23"}],"displaytype":"detail","filename":"VMS53_3_365_369.pdf","filesize":[{"value":"496.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"VMS53_3_365_369.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/19613/files/VMS53_3_365_369.pdf"},"version_id":"957f3baf-0dae-476f-b28f-bf270a9f4cbb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IL-2-like activity","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro assay","subitem_subject_scheme":"Other"},{"subitem_subject":"miniature swine","subitem_subject_scheme":"Other"},{"subitem_subject":"monitor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ミニブタの同種末梢血リンパ球前処置による in vitro IL-2様活性の早期検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミニブタの同種末梢血リンパ球前処置による in vitro IL-2様活性の早期検出"}]},"item_type_id":"2","owner":"2","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-11"},"publish_date":"2008-08-11","publish_status":"0","recid":"19613","relation_version_is_last":true,"title":["ミニブタの同種末梢血リンパ球前処置による in vitro IL-2様活性の早期検出"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:10:26.360915+00:00"}