@article{oai:nagasaki-u.repo.nii.ac.jp:00019812, author = {Kawai, Kioko and Shigematsu, Kazuto and Matsuo, Kenji and Kanetake, Hiroshi and Saito, Yutaka and Tsuchiyama, Hideo}, issue = {1/4}, journal = {Acta Medica Nagasakiensia}, month = {Oct}, note = {Quite rare enzyme histochemical and ultrastructural observations on non-functioning adenoma (NFA) are presented and discussed in detail together with the steroid contents since we obtained NFAs at surgery from two patients. Ultrastructurally, each adenoma was composed of 3 different types of cells ; type 1, type 2 and type 3 cells, most of which in both cases showed weak activity of 3β-hydroxysteroid dehydrogenase (3β-HSD) but cells with strong activity were sporadically scattered throughout the adenomas. Some of the type 3 cells contained well-developed organelles resembling those in functioning adenoma (FA) though fewer in number, indicative of having an ability to produce corticosteroids although the amount would be less than that of FA. No essential qualitative difference lies between NFA and FA in cellular components or in organellar features except for a decrease in number of the cells with well-developed organelles in NFA. The mean values of corticosteroid contents were lower than those in FA, Acta Medica Nagasakiensia. 1986, 31(1-4), p.189-203}, pages = {189--203}, title = {"Non-functioning Adrenocortical Adenomas" -Enzyme Histochemistry, Ultrastructure and Steroid Contents-}, volume = {31}, year = {1986} }