@article{oai:nagasaki-u.repo.nii.ac.jp:00019872,
 author = {Omagari, Katsuhisa and Imanishi, Takeo and Makiyama, Kazuya},
 issue = {1/4},
 journal = {Acta Medica Nagasakiensia},
 month = {Dec},
 note = {Flow cytometric analysis of the cellular DNA content was conducted using paraffin-embedded liver tissues. Of the 488 cases examined, 413 (84.6%) cases were suitable for analysis. Of these, 296 (88.9%) were diploid and 37 (11.1%) were aneuploid. The ploidy pattern was unaffected by patients' sex and age. Long-term stored tissues were as suitable for analysis as short-term stored ones. An aneuploid pattern was more frequently found in hepatocellular carcinoma (HCC) (17/43,39.5%) than in non-neoplastic liver conditions (20/284,7.0%) (p<0.01). The ploidy pattern was determined to be one of the most important prognostic factors in HCC. An aneuploid pattern was also found in non-neoplastic liver conditions such as liver cirrhosis (LC) and chronic hepatitis caused by hepatitis virus (CH). It seems that the ploidy pattern and proliferative index (S+G2M fraction) do not always affect carcinogenesis in non-neoplastic liver conditions. Thus, flow cytometric analysis of the cellular DNA content using paraffin-embedded specimens is useful for determining the prognostic significance in HCC, although the significance is uncertain in non-neoplastic liver conditions., Acta Medica Nagasakiensia. 1992, 37(1-4), p.5-8},
 pages = {5--8},
 title = {Flow Cytometric Analysis of the Cellular DNA Content in Various Liver Diseases},
 volume = {37},
 year = {1992}
}