@article{oai:nagasaki-u.repo.nii.ac.jp:00019923,
 author = {Miyashita, Kosei},
 issue = {1},
 journal = {Acta Medica Nagasakiensia},
 month = {Jan},
 note = {Differences in the proliferative activity of cancer cells between the primary lesion and the metastatic lymph node of solid tumors were studied in subcutaneously transplanted rat tumor AH109A and human gastric cancer. The cellular RNA content (RNA index, RI), colony formation assay (plating efficiency, PE) and  Brdurd labeling index (L1) were used as indicators for the proliferative activity of cancer cells, In the experiment with transplanted rat tumor, RI, PE, and LI fell off significantly over time at 1, 2 and 3 weeks after transplantation. On comparison of the primary lesion and the meta static lymph node, the DNA index (DI) remained unchanged but RI increased significantly in the metastatic lymph node. PE and LI Likewise showed significantly high values in the metastatic lesion, When the DNA-RNA indices for 19 cases of human gastric cancer were studied, DI remained almost unchanged in the primary lesion and the metastatic lymph node but RI showed high values in the lymph node. Therefore, the proliferative activity of cancer cells is considered to be higher in the metastatic lymph node than in the primary lesion, which is very significant for the progression of the tumor. On the other hand, chemotherapy can be expected to be more effective in the metastatic lymph node than in the primary lesion. The present study may provide a theoretical basis for reduction surgery on the primary lesion followed by other techniques on the secondary lesion., Acta Medica Nagasakiensia. 1993, 38(1), p.21-27},
 pages = {21--27},
 title = {A Comparative Study of Cell Proliferative Activity between the Primary Tumor and the Metastatic Lymph Node},
 volume = {38},
 year = {1993}
}