{"created":"2023-05-15T16:30:44.975437+00:00","id":1993,"links":{},"metadata":{"_buckets":{"deposit":"8abeebfc-5524-4904-97f8-9fe7f7cc992c"},"_deposit":{"created_by":2,"id":"1993","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1993"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:00001993","sets":["10:11"]},"author_link":["9208","9211","9213","9212","9209","9214","9207","9210","9206"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"551","bibliographicPageStart":"545","bibliographicVolumeNumber":"495","bibliographic_titles":[{"bibliographic_title":"Clinica Chimica Acta"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Autoimmune reactions and subsequent inflammation may underlie spermatogenic dysfunction and endometriosis-related infertility.The aim of this study is to identify disease-specific antigens in immune complexes (ICs) in seminal plasma (SP) and in follicular fluid (FF).\nMethods: Immune complexome analysis, in which nano-liquid chromatography-tandem mass spectrometry is employed to comprehensively identify antigens incorporated into ICs in biological fluids, was performed for specimens collected from infertile couples undergoing assisted reproduction.Forty-two male patients consisting of subjects with oligozoospermia (n=6), asthenozoospermia (n=8), and normal semen analysis (n=28).\n Fifty-eight female patients consisting of subjects with ovarian endometriosis (n=10) and control women without disease (n=48).\nResults: Four disease-specific antigens were identified in subjects with oligozoospermia, while five disease-specific antigens were detected in subjects with asthenozoospermia, some of which are involved in sprematogenesis. Eight antigens were detected only in subjects with endometriosis.\nConclusion: Functional characteristics of disease-specific antigens were found to correspond to the pathogenesis of male and female infertility. The formation of ICs may contribute to spermatogenic dysfunction and endometriosis-related infertility via loss of function of the related proteins.\n Immune complexome analysis is expected to be a valuable tool for the investigation of novel diagnostic methods and treatment strategies for infertility.","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Clinica Chimica Acta, 495, pp.545-551; 2019","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.cca.2019.05.031","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"c 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-8981","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Murakami, Naoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitajima, Michio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohyama, Kaname"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aibara, Nozomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taniguchi, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wei, Mian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitajima, Yuriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Kiyonori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuzaki, Hideaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-12-18"}],"displaytype":"detail","filename":"CCA495_545.pdf","filesize":[{"value":"274.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CCA495_545.pdf","url":"https://nagasaki-u.repo.nii.ac.jp/record/1993/files/CCA495_545.pdf"},"version_id":"daecbf24-8908-4946-ae4b-447ce1855581"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"immune complex antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"immune complexome analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"infertility","subitem_subject_scheme":"Other"},{"subitem_subject":"spermatogenic dysfunction","subitem_subject_scheme":"Other"},{"subitem_subject":"spermatogenic dysfunction","subitem_subject_scheme":"Other"},{"subitem_subject":"endometriosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women"}]},"item_type_id":"2","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-31"},"publish_date":"2020-05-31","publish_status":"0","recid":"1993","relation_version_is_last":true,"title":["Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-16T03:54:19.664999+00:00"}