@article{oai:nagasaki-u.repo.nii.ac.jp:00001999, author = {Ueda, Atsushi and Higuchi, Mei and Umeno, Tomohiro and Tanaka, Masakazu}, issue = {2}, journal = {HETEROCYCLES}, month = {Nov}, note = {An enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans has been achieved in four steps from α,β-unsaturated ketones and dimethyl malonate by peptide-catalyzed asymmetric Michael addition and diastereoselective construction of tetrahydropyran rings by Kishi’s reductive cyclization as key steps. A variety of α,β-unsaturated ketones were converted to the 1,4-products with high enantioselectivities (83-98% ee)., HETEROCYCLES, 99(2), pp.989-1002; 2019}, pages = {989--1002}, title = {Enantioselective Synthesis of 2,4,5-Trisubstituted Tetrahydropyrans via Peptide-Catalyzed Michael Addition Followed by Kishi’s Reductive Cyclization}, volume = {99}, year = {2018} }