@article{oai:nagasaki-u.repo.nii.ac.jp:02000072,
 author = {Hanada, Masatoshi and Ishimatsu, Yuji and Sakamoto, Noriho and Akiyama, Yoshiko and Kido, Takashi and Ishimoto, Hiroshi and Oikawa, Masato and Nagura, Hiroki and Takeuchi, Rina and Sato, Shuntaro and Takahata, Hideaki and Mukae, Hiroshi and Kozu, Ryo},
 issue = {1},
 journal = {Scientific Reports},
 month = {Jun},
 note = {This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung disease. We measured urinary N-titin/Cr. Furthermore, we measured the cross-sectional areas of the pectoralis muscles above the aortic arch (PMCSA) and erector spinae muscles of the 12th thoracic vertebra muscles (ESMCSA) to assess muscle mass until 1 year. We examined the correlation between urinary N-titin/Cr and the change in muscle mass. We plotted receiver operating characteristic curves to estimate the cut-off points for urinary N-titin/Cr for distinguishing the greater-than-median and smaller-than-median reduction of muscle mass after 1 year. We enrolled 68 patients with interstitial lung disease. The median urinary N-titin/Cr value was 7.0 pmol/mg/dL. We observed significant negative correlations between urinary N-titin/Cr and changes in the PMCSA after 1 year (p < 0.001) and changes in the ESMCSA after 6 months (p < 0.001) and 1 year (p < 0.001). The cut-off points for urinary N-titin/Cr were 5.2 pmol/mg/dL and 10.4 pmol/mg/dL in the PMCSA and ESMCSA, respectively. In summary, urinary N-titin/Cr may predict muscle loss in the long-term and act as a clinically useful biomarker reflecting muscle damage., Scientific Reports, 13(1), art. no. 9723; 2023},
 title = {Urinary titin N-fragment as a predictor of decreased skeletal muscle mass in patients with interstitial lung diseases},
 volume = {13},
 year = {2023}
}