{"created":"2023-07-25T02:37:45.337168+00:00","id":2000077,"links":{},"metadata":{"_buckets":{"deposit":"de6fe13b-3e87-4866-a88f-dcad0302728c"},"_deposit":{"created_by":6,"id":"2000077","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2000077"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02000077","sets":["10:11"]},"author_link":[],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageStart":"art. no. e34004","bibliographicVolumeNumber":"102","bibliographic_titles":[{"bibliographic_title":"Medicine","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Dexmedetomidine is used for the sedation method in the case of endoscopic retrograde cholangiopancreatography (ERCP) for the purpose of relieving patient anxiety. It has been reported that CO2 accumulated during sedation causes an arousal reaction, so how to normalize CO2 during sedation can be improved by administration of the minimum necessary sedative. Nasal High Flow oxygen therapy (NHF) uses a mild positive pressure load that improves carbon dioxide washout and reduces rebreathing to improve respiratory function and therefore is widely used to prevent hypoxemia and hypercapnia. In this study, we will investigate whether the upper airway patency would be maintained and the hypercapnia and hypoxemia during sedation would be prevented, by applying NHF as a respiratory management method to patients undergoing ERCP under sedation. Methods/design: In a randomized comparative study of 2 groups, the NHF device use group and the nasal cannula use group, for adult patients who visited the Nagasaki University Hospital and underwent ERCP examination under sedation. For sedation, Dexmedetomidine will be used in combination with and Midazolam and evaluation by anesthesiologist. In addition, as an analgesic, pethidine hydrochloride was administered intravenously. The total dose of the analgesic pethidine hydrochloride used in combination is used as the primary endpoint. As a secondary evaluation item, the percutaneous CO2 concentration is evaluated with a TCO2 monitor to examine whether it is effective in preventing hypercapnia. Furthermore, we will evaluate the incidence of hypoxemia with a percutaneous oxygen saturation value of 90% or less, and examine whether the use of equipment is effective in preventing the occurrence of hypercapnia and hypoxemia. Discussion: The purpose of this study was to obtain evidence for the utility of NHF as a potential therapeutic device for patients undergoing an ERCP under sedation, assessed by determining if the incidence rates of hypercapnia and hypoxemia decreased in the NHF device group, compared to the control group that did not use of this device. Abbreviations: AUC = area under the curve, ERCP = endoscopic retrograde cholangiopancreatography, NHF = Nasal High Flow, PtcCO2 = transcutaneous CO2.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Medicine, 102(23), art. no. e34004; 2023","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Kluwer Health, Inc","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/MD.0000000000034004","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0025-7974","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ayuse, Takao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurata, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Tomotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuroda, Shohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ichinomiya, Taiga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yano, Rintaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mishima, Gaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ozawa, Eisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tatkov, Stanislav","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Shuntaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kazuhiko, Nakao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hara, Tetsuya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-25"}],"filename":"M102_e34004.pdf","filesize":[{"value":"432 KB"}],"format":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2000077/files/M102_e34004.pdf"},"version_id":"5cadcf28-80fd-43d1-80b4-11c8527e360a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hypercapnia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intravenous anesthesia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nasal High Flow","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Examination of stabilization of sedation by Nasal High Flow in patients with endoscopic retrograde cholangiopancreatography during sedation using Dexmedetomidine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Examination of stabilization of sedation by Nasal High Flow in patients with endoscopic retrograde cholangiopancreatography during sedation using Dexmedetomidine","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-25"},"publish_date":"2023-07-25","publish_status":"0","recid":"2000077","relation_version_is_last":true,"title":["Examination of stabilization of sedation by Nasal High Flow in patients with endoscopic retrograde cholangiopancreatography during sedation using Dexmedetomidine"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-07-25T02:46:31.640560+00:00"}