{"created":"2023-11-28T01:40:18.103693+00:00","id":2000400,"links":{},"metadata":{"_buckets":{"deposit":"ba469960-37e4-4d05-a94e-485bb9297bcd"},"_deposit":{"created_by":6,"id":"2000400","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2000400"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02000400","sets":["8:9"]},"author_link":[],"control_number":"2000400","item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"art. no. 707","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Supportive Care in Cancer","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Oral mucositis (OM) is a side effect associated with cancer treatment. Hangeshashinto (HST), a Kampo medicine, was originally prescribed to treat diarrhea, gastritis, and stomatitis. Several reports have described the effects of HST for OM induced by chemotherapy in patients with gastric or colorectal cancer. In this study, the effects of HST for prevention of OM were investigated in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: Thirty patients scheduled to receive allogeneic grafts were enrolled from July 2020 to December 2021. They were randomly assigned to two groups and instructed to wash their mouth using HST dissolved in saline solution or using only saline solution three times a day. The observation period was from the initiation date of the conditioning regimen to the date of engraftment, and the end point was the incidence of OM. Results: Eighteen patients developed OM, the most severe of which was Grade (G)3. There was no significant difference in the incidence of OM between the HST group and the control group. However, a negative correlation tended to be observed between the duration using HST use and the duration of OM (G2–3: P = 0.027, G3: P = 0.047). Conclusions:  The present study demonstrated that HST use did not clearly inhibit onset of OM but showed a tendency to inhibit OM exacerbation. However, further studies are necessary to fully understand the effects of HST on OM in patients undergoing HSCT. Trial registration: This study was registered in the Japan Registry of Clinical Trials on 7 May 2020 (jRCTs071200012).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Supportive Care in Cancer, 31(12), art. no. 707; 2023","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00520-023-08175-7","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2023 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0941-4355","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshimatsu, Masako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawashita, Yumiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Soutome, Sakiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murata, Maho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawayama, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurogi, Tadafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakao, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyazaki, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Umeda, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ukai, Takashi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-28"}],"filename":"SCC31_707.pdf","filesize":[{"value":"625 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2000400/files/SCC31_707.pdf"},"version_id":"dd715235-c2e2-4c35-960b-79bf3c26612f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hangeshashinto","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral mucositis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hematopoietic stem cell transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Conditioning regimen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hangeshashinto for prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized phase II study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hangeshashinto for prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized phase II study","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-28"},"publish_date":"2023-11-28","publish_status":"0","recid":"2000400","relation_version_is_last":true,"title":["Hangeshashinto for prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized phase II study"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-11-28T05:06:56.333510+00:00"}