{"created":"2023-11-28T01:47:04.243760+00:00","id":2000401,"links":{},"metadata":{"_buckets":{"deposit":"17b55f7a-c6b5-4232-901c-12493d3ee7a1"},"_deposit":{"created_by":6,"id":"2000401","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2000401"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02000401","sets":["8:9"]},"author_link":[],"control_number":"2000401","item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-11-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"art. no. 23","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Hereditary Cancer in Clinical Practice","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: In Japan, genetic testing, surveillance, and risk-reducing surgery for hereditary breast and ovarian cancer (HBOC) syndrome have been covered by the Japanese national insurance system since April 2020. On the other hand, the current situation is that medical care, including surveillance of undiagnosed (cancer-free) patients, is self-funded even for individuals with HBOC. We report a case in which breast cancer was diagnosed at an early stage during surveillance for cancer-free HBOC at the patient’s own expense, and risk-reducing surgery was performed at the same time as treatment for breast cancer. Case presentation: The patient was a 63-year-old woman. Her sister had a history of breast cancer in her 30s and was found to be a BRCA2 pathogenic variant carrier by genetic testing. The patient therefore presented to the genetic department of our hospital and underwent genetic testing (out-of-pocket). A pathogenic variant was found at the same site. During annual breast and ovarian surveillance at the patient’s own expense, a physician with sufficient expertise in contrast-enhanced breast magnetic resonance imaging (MRI) noticed a change in the contrast enhancement pattern on breast MRI and performed needle biopsy, revealing ductal carcinoma in situ. At the request of the patient, she underwent concurrent contralateral risk-reducing mastectomy and risk-reducing salpingo-oophorectomy in addition to breast cancer treatment. Conclusions: We encountered a case in which cancer treatment and risk-reducing surgery were performed at the same time for a pathogenic variant carrier who was very anxious about developing cancer. Surveillance of cancer-free BRCA1/2 mutation carriers and expansion of insurance coverage for surgery are important future issue.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Hereditary Cancer in Clinical Practice, 21(1), art. no. 23; 2023","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13053-023-00268-y","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","subitem_rights_language":"en"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1897-4287","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumoto, Megumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takao, Mami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miura, Shoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hasegawa, Yuri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Otsubo, Ryota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hayashi, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Isomoto, Ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miura, Kiyonori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagayasu, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-11-28"}],"filename":"HCCP21_23.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2000401/files/HCCP21_23.pdf"},"version_id":"fac1e8ed-41b1-48c8-b448-1a0a2fef6ae5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hereditary breast and Ovarian cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BRCA1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BRCA2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Contralateral risk-reducing mastectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Risk-reducing salpingo-oophorectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-11-28"},"publish_date":"2023-11-28","publish_status":"0","recid":"2000401","relation_version_is_last":true,"title":["Simultaneous bilateral mastectomy and RRSO for BRCA2-positive non-invasive breast cancer in Japan: a case report and analysis of initial experience"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-11-28T05:10:06.737395+00:00"}