| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-12-07 |
| タイトル |
|
|
タイトル |
BioFire FilmArray Pneumonia Panel enhances detection of pathogens and antimicrobial resistance in lower respiratory tract specimens |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Automated system |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lower respiratory tract infections |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Multiplex molecular assay |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rapid detection |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kosai, Kosuke
Akamatsu, Norihiko
Ota, Kenji
Mitsumoto-Kaseida, Fujiko
Sakamoto, Kei
Hasegawa, Hiroo
Izumikawa, Koichi
Mukae, Hiroshi
Yanagihara, Katsunori
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: This study investigated the diagnostic utility of the BioFire FilmArray Pneumonia Panel (PN panel), an automated and multiplexed nucleic acid detection system that rapidly detects 26 pathogens (18 bacteria and eight viruses) and seven antimicrobial resistance markers in a single assay. Methods: We analyzed the targets in lower respiratory tract specimens using the PN panel and compared the detection results with those of bacterial culture methods and antimicrobial susceptibility testing. Results: Of the 57 samples analyzed, the PN panel detected 97 targets (84 bacteria, four viruses, and nine antimicrobial resistance markers). Detection of bacteria and antimicrobial resistance was three times greater than that of the bacterial culture (25 bacteria and two resistant isolates) against the targets available in the panel. The overall positive and negative percent agreements between the PN panel and culture methods for bacterial detection were 100.0% and 92.9%, respectively. Multiple pathogens were detected by the PN panel in 24 samples (42.1%), ranging from two pathogens in 11 samples (19.3%) to six pathogens in one sample (1.8%). The PN panel semiquantitatively detected higher copies (≥ 106 copies/mL) of bacterial targets if the bacteria were positive by the culture method. In contrast, the semiquantitative values obtained by the panel varied (104 to 107 ≤ copies/mL) among bacteria that were negative by the culture method. Conclusions: The PN panel enhanced the detection of pathogens and antimicrobial resistance markers in lower respiratory tract specimens. |
|
言語 |
en |
| 書誌情報 |
en : Annals of Clinical Microbiology and Antimicrobials
巻 21,
号 1,
p. art. no. 24,
発行日 2022-06-04
|
| 出版者 |
|
|
出版者 |
BioMed Central Ltd |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14760711 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1186/s12941-022-00512-8 |
| 権利 |
|
|
権利情報 |
© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
|
言語 |
en |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Annals of Clinical Microbiology and Antimicrobials, 21(1), art. no. 24; 2022 |
|
言語 |
en |
ACMA21_24.pdf (752 KB)
