{"created":"2024-03-11T02:41:00.747679+00:00","id":2000598,"links":{},"metadata":{"_buckets":{"deposit":"e1ad6c94-ea63-4291-a9c4-89e2b83bb1c8"},"_deposit":{"created_by":6,"id":"2000598","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2000598"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02000598","sets":["35:36"]},"author_link":[],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"art. no. 4701","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The length of telomeres located at the ends of chromosomes has attracted attention as an indicator of cellular and individual aging. Various diseases or stresses cause telomere shortening, and it has been reported that alcohol use disorder patients actually have shorter telomeres than healthy patients. However, the factors that contribute to the reduction in telomere length among alcohol use disorder patients have not been clarifed in detail. Therefore, in this study, we explored the factors that reduce telomere length in alcohol use disorder patients. A questionnaire survey and a measurement of leukocyte telomere length were conducted among alcohol use disorder patients. The mean telomere length of leukocyte was measured by ∆∆Ct analysis using a real-time PCR. We compared the telomere length between alcohol use disorder patients and the control group (Japanese special health check-up examinee). Moreover, we searched for factors associated with telomere length from drinking/smoking characteristics and history of comorbidities. A total of 74 subjects had alcohol use disorder, and 68 were in the control group. Compared to the control group, alcohol use disorder patients had signifcantly shorter telomere lengths (p< 0.001). A multivariate analysis revealed that a longer duration of smoking resulted in a signifcantly shorter telomere length (p= 0.0129). In addition, a comparison of the telomere length between the groups with and without a history of sufering from each disease revealed that telomere length was signifcantly shorter in the group with diabetes than in the group without diabetes (p= 0.0371). This study reveals that in individuals with alcohol dependence, particularly, prolonged smoking habits and the presence of diabetes contribute to telomere shortening. Medication and support for abstinence from alcohol has been mainly provided for alcohol  use disorder patients. Our fndings demonstrate a potential support approach via smoking cessation programs and controlling diabetes, which may be helpful to suppress the shortening of healthy life expectancy among alcohol use disorder patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Scientific Reports, 14(1), art. no. 4701; 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-024-55195-2","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2024","subitem_rights_language":"en"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"EISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inomata, Shinsaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arima, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukuda, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ozawa, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Taro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-11"}],"filename":"SR14_4701.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2000598/files/SR14_4701.pdf"},"version_id":"5bc6aa47-98e3-42b3-9afb-ba7b1e1ac0f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alcohol use disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Telomere length","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Smoking","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Smoking and diabetes cause telomere shortening among alcohol use disorder patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Smoking and diabetes cause telomere shortening among alcohol use disorder patients","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["36"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-11"},"publish_date":"2024-03-11","publish_status":"0","recid":"2000598","relation_version_is_last":true,"title":["Smoking and diabetes cause telomere shortening among alcohol use disorder patients"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-03-11T02:46:54.030867+00:00"}