@phdthesis{oai:nagasaki-u.repo.nii.ac.jp:02000737,
 author = {牧野, 淳},
 month = {Dec},
 note = {Introduction: Because of increasing medical costs and antibiotic resistance, a blood-culture contamination rate of less than 3% is recommended. This study involved the conceptualization of a novel ICU blood culture sample-collection protocol and an investigation of the effect of its implementation on ICU blood culture contamination rate. Considering the difficulty of sample collection via venipuncture in ICU patients, blood culture sample collection via single venipuncture was evaluated as an alternative method. Materials and Methods: Adults who were admitted to the ICU and provided blood culture samples collected between June 1, 2018, and May 31, 2021, were prospectively enrolled in this single-center, interventional study. The primary outcome was the change in the blood-culture contamination rate from before to after the introduction of the seven-item ICU blood culture protocol (Intervention 1); the secondary outcome was the change in the blood-culture contamination rate and true positive rate from before to after the introduction of the single venipuncture method (Intervention 2). Results: During the study period, there were 524 sets of ICU blood culture sample collections. Intervention 1 significantly decreased the blood-culture contamination rate from 20% to 1.8% (p=0.01). Compared with the double venipuncture method, Intervention 2 did not significantly increase the blood-culture contamination or true positive rate. Discussion: The implementation of the ICU blood-culture sample-collection protocol and subsequent improvements in the quality of blood-culture sample collection significantly decreased the blood-culture contamination rate. The single venipuncture method did not increase the rate of contamination; however, the clinical usefulness of the single venipuncture method should be ascertained., 長崎大学学位論文 学位記番号:博(医歯薬)甲第1563号 学位授与年月日:令和5年12月6日, Author: Jun Makino, Satoshi Kakiuchi, Takeshi Tanaka, Masato Tashiro, and Koichi Izumikawa, Citation: ACTA MEDICA NAGASAKIENSIA, 67(2), pp.41−48; 2024, Nagasaki University (長崎大学), 博士(医学) (2023-12-06)},
 school = {Nagasaki University (長崎大学)},
 title = {Introduction of ICU blood culture protocols and the effect on rates of contamination: A single-center, non-randomized interventional study},
 year = {2023}
}