{"created":"2024-06-18T04:50:58.511772+00:00","id":2000947,"links":{},"metadata":{"_buckets":{"deposit":"0c40feae-04f6-4c14-8eb6-846fc8b33488"},"_deposit":{"created_by":6,"id":"2000947","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2000947"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02000947","sets":["8:9"]},"author_link":[],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"art. no. 155","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"BMC Research Notes","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and objective: Aspartame (L-aspartyl L-phenylalanine methyl ester) is an artificial sweetener widely used as a sugar substitute. There are concerns regarding the effects of high aspartame doses on the kidney owing to oxidative stress; however, whether the maximum allowed dose of aspartame in humans affects the kidneys remains unknown. Therefore, in this study, we investigated whether the maximum allowed dose of aspartame in humans affects the kidneys. Methods: In this study, animals were fed a folate-deficient diet to mimic human aspartame metabolism. Eight-week-old ICR mice were divided into control (CTL), 40 mg/kg/day of aspartame-administered (ASP), folate-deficient diet (FD), and 40 mg/kg/day of aspartame-administered with a folate-deficient diet (FD + ASP) groups. Aspartame was administered orally for eight weeks. Thereafter, we evaluated aspartame’s effect on kidneys via histological analysis. Results: There were no differences in serum creatinine and blood urea nitrogen levels between the CTL and ASP groups or between the FD and FD + ASP groups. There was no histological change in the kidneys in any group. The expression of superoxide dismutase and 4-hydroxy-2-nonenal in the kidney did not differ between the CTL and ASP groups or the FD and FD + ASP groups. Conclusion: Our findings indicate that the allowed doses of aspartame in humans may not affect kidney function or oxidative states.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BMC Research Notes, 17, art. no.155; 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13104-024-06816-6","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1756-0500","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Torigoe, Kenta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Torigoe, Miki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oka, Satoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Obata, Yoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishino, Tomoya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-18"}],"filename":"BMCRN17_155.pdf","filesize":[{"value":"4.4 MB"}],"format":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2000947/files/BMCRN17_155.pdf"},"version_id":"26b11c09-cb60-4890-b17e-93e31bed5a79"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aspartame","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kidney","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Food safety","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-18"},"publish_date":"2024-06-18","publish_status":"0","recid":"2000947","relation_version_is_last":true,"title":["Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-06-18T04:54:22.856832+00:00"}