{"created":"2024-10-21T04:51:08.019961+00:00","id":2001474,"links":{},"metadata":{"_buckets":{"deposit":"ffc1dc28-f391-499e-841f-8151cae39bfa"},"_deposit":{"created_by":6,"id":"2001474","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2001474"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02001474","sets":["10:22:24"]},"author_link":[],"item_5_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒトVγ9Vδ2 T cells細胞のAspergillus fumigatusとその他の糸状真菌に対する抗真菌活性評価","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"art. no. e03614-23","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Microbiology Spectrum","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-06-05"}]},"item_5_degree_grantor_62":{"attribute_name":"item_5_degree_grantor_62","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"Nagasaki University (長崎大学)"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17301","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Invasive aspergillosis (IA) and mucormycosis are life-threatening diseases, especially among immunocompromised patients. Drug-resistant Aspergillus fumigatus strains have been isolated worldwide, which can pose a serious clinical problem. As IA mainly occurs in patients with compromised immune systems, the ideal therapeutic approach should aim to bolster the immune system. In this study, we focused on Vγ9Vδ2 T cells that exhibit immune effector functions and examined the possibility of harness­ ing this unconventional T cell subset as a novel therapeutic modality for IA. A potent antifungal effect was observed when A. fumigatus (Af293) hyphae were challenged by Vγ9Vδ2 T cells derived from peripheral blood. In addition, Vγ9Vδ2 T cells exhibited antifungal activity against hyphae of all Aspergillus spp., Cunninghamella bertholletiae, and Rhizopus microsporus but not against their conidia. Furthermore, Vγ9Vδ2 T cells also exhibited antifungal activity against azole-resistant A. fumigatus, indicating that Vγ9Vδ2 T cells could be used for treating drug-resistant A. fumigatus. The antifungal activity of Vγ9Vδ2 T cells depended on cell-to-cell contact with A. fumigatus hyphae, and degranulation characterized by CD107a mobilization seems essential for this activity against A. fumigatus. Vγ9Vδ2 T cells could be developed as a novel modality for treating IA or mucormycosis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"長崎大学学位論文 学位記番号:博(医歯薬)甲第1619号 学位授与年月日:令和6年6月5日","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Satoru Koga, Takahiro Takazono, Hodaka Namie, Daisuke Okuno, Yuya Ito, Nana Nakada, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Naoki Iwanaga, Masato Tashiro, Noriho Sakamoto, Akira Watanabe, Koichi Izumikawa, Katsunori Yanagihara, Yoshimasa Tanaka, Hiroshi Mukae","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Microbiology Spectrum, 12(4), art. no. e03614-23; 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_69":{"attribute_name":"item_5_description_69","attribute_value_mlt":[{"subitem_description":"Nagasaki University (長崎大学), 博士(医学) (2024-06-05)","subitem_description_type":"Other"}]},"item_5_dissertation_number_65":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医歯薬第1619号"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Koga, Satoru","nameLang":"en"}]}]},"item_5_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Microbiology","subitem_publisher_language":"en"}]},"item_5_relation_12":{"attribute_name":"item_5_relation_12","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/spectrum.03614-23","subitem_relation_type_select":"DOI"}}]},"item_5_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10069/0002001042","subitem_relation_type_select":"HDL"}}]},"item_5_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 Koga et al. This is an open-access  article distributed under the terms of the Creative Commons Attribution 4.0 International license.","subitem_rights_language":"en"}]},"item_5_source_id_7":{"attribute_name":"item_5_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"2165-0497","subitem_source_identifier_type":"EISSN"}]},"item_5_text_67":{"attribute_name":"item_5_text_67","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"課程博士"}]},"item_5_version_type_16":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古賀, 哲","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-21"}],"filename":"ISYK1619_Koga.pdf","filesize":[{"value":"1 MB"}],"format":"application/pdf","url":{"objectType":"fulltext","url":"https://nagasaki-u.repo.nii.ac.jp/record/2001474/files/ISYK1619_Koga.pdf"},"version_id":"2f06dcd9-5b33-4b8f-8b80-a5597a9db180"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"γδ T cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"invasive aspergillosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"filamentous fungi","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitrogen-containing  bisphosphonate prodrug","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Human Vγ9Vδ2 T cells exhibit antifungal activity against Aspergillus fumigatus and other filamentous fungi","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human Vγ9Vδ2 T cells exhibit antifungal activity against Aspergillus fumigatus and other filamentous fungi","subitem_title_language":"en"}]},"item_type_id":"5","owner":"6","path":["24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-21"},"publish_date":"2024-10-21","publish_status":"0","recid":"2001474","relation_version_is_last":true,"title":["Human Vγ9Vδ2 T cells exhibit antifungal activity against Aspergillus fumigatus and other filamentous fungi"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2024-10-21T04:57:46.595216+00:00"}