{"created":"2025-01-14T01:12:38.878551+00:00","id":2001751,"links":{},"metadata":{"_buckets":{"deposit":"a9d28ed4-9957-462e-a299-1c38ebea898e"},"_deposit":{"created_by":6,"id":"2001751","owner":"6","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"2001751"},"status":"published"},"_oai":{"id":"oai:nagasaki-u.repo.nii.ac.jp:02001751","sets":["8:9"]},"author_link":[],"control_number":"2001751","item_2_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-12-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"art. no. 110865","bibliographicVolumeNumber":"135","bibliographic_titles":[{"bibliographic_title":"Clinical Biochemistry","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized. Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020. For the analysis, the patients were split into the severe (n = 35) and non-severe (n = 28) groups on the basis of their COVID-19 symptoms. Results: We found that neither serum IC concentration nor IC antigen number was associated with COVID-19 severity. However, we identified six IC antigens, which were significantly enriched in the severe versus non-severe group. These IC antigens were all derived from human proteins, namely haptoglobin, the serum amyloid A-2 protein, the serum amyloid A-1 protein, clusterin, and lipopolysaccharide-binding protein, and complement-factor-H-related protein 3. Meanwhile, we found no association between COVID-19 severity and IC antigens derived from SARS-CoV-2 proteins. Collectively, the six IC antigens predicted COVID-19 severity with a moderate degree of accuracy (area under the receiver operating characteristic curve = 0.90, sensitivity = 94 %, specificity = 79 %). Conclusions: The IC antigen signature identified in this study may have important implications for the diagnosis and treatment of severe COVID-19.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_63":{"attribute_name":"item_2_description_63","attribute_value_mlt":[{"subitem_description":"Clinical Biochemistry, 135, art. no. 110865; 2024","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc.","subitem_publisher_language":"en"}]},"item_2_relation_12":{"attribute_name":"item_2_relation_12","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.clinbiochem.2024.110865","subitem_relation_type_select":"DOI"}}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024 The Canadian Society of Clinical Chemists. Published by Elsevier Inc.  This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.","subitem_rights_language":"en"}]},"item_2_source_id_7":{"attribute_name":"item_2_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"00099120","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Moriishi, Marino","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takazono, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hashizume, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aibara, Nozomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kutsuna, Yuki Jimbayashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okamoto, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawai, Toyomitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hoshino, Teppei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukuda, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Awaya, Yukikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamanashi, Hirotomo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furusato, Yuichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yanagihara, Toyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miyamoto, Hirotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Kayoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kodama, Yukinobu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mizukami, Shusaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakamoto, Noriho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakamoto, Kei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yanagihara, Katsunori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Izumikawa, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maeda, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakashima, Mikiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukushima, Kiyoyasu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mukae, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohyama, Kaname","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-12-20"}],"filename":"CB135_110865.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://nagasaki-u.repo.nii.ac.jp/record/2001751/files/CB135_110865.pdf"},"version_id":"89061179-5497-449b-9e0b-7a3fb806bc08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"COVID-19","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SARS-CoV-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune complexome analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity","subitem_title_language":"en"}]},"item_type_id":"2","owner":"6","path":["9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-14"},"publish_date":"2025-01-14","publish_status":"0","recid":"2001751","relation_version_is_last":true,"title":["Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2025-01-14T02:34:06.139869+00:00"}