| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-18 |
| タイトル |
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タイトル |
Distinct clinical outcomes based on multiple serum cytokine and chemokine profiles rather than autoantibody profiles and ultrasound findings in rheumatoid arthritis: a prospective ultrasound cohort study |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Fukui, Shoichi
Michitsuji, Tohru
Endo, Yushiro
Nishino, Ayako
Furukawa, Kaori
Morimoto, Shimpei
Shimizu, Toshimasa
Umeda, Masataka
Sumiyoshi, Remi
Koga, Tomohiro
Iwamoto, Naoki
Tamai, Mami
Origuchi, Tomoki
van, Schie Karin A J
Ueki, Yukitaka
Eiraku, Nobutaka
Yoshitama, Tamami
Matsuoka, Naoki
Suzuki, Takahisa
Okada, Akitomo
Hamada, Hiroaki
Ayano, Masahiro
Hidaka, Toshihiko
Tsuru, Tomomi
Maeda, Takahiro
Huizinga, Tom W J
Toes, René E M
Kawakami, Atsushi
Kawashiri, Shin-Ya
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objectives: To evaluate the potential of clinical factors, ultrasound findings, serum autoantibodies, and serum cytokine and chemokine profiles as predictors of clinical outcomes in rheumatoid arthritis (RA). Patients and methods: We included 200 patients with RA treated with biological and targeted synthetic disease-modifying antirheumatic drugs in a prospective multicentre ultrasound cohort study. Their serum levels of multiple cytokines and chemokines, rheumatoid factors, and serum autoantibodies (anti-cyclic citrullinated peptide-2 (anti-CCP2) and anti-carbamylated protein antibodies) were measured at baseline, 3 months and 12 months. Results: Dimensionality reduction using 38 cytokines and chemokines demonstrated four distinct clusters that differed significantly regarding the frequencies of remission defined by clinical composite measures and ultrasound evaluations. Prominent differences in IL-1β, IL-5, IL-7, IL-10, IFNγ, GRO, IP-10, MCP-1 and MIP-1β characterised the between-cluster differences. Two distinct groups made of four clusters showed a significant difference in IgM-anti-CCP2 positivity. The least absolute shrinkage and selection operator regression of 38 cytokines and chemokines for Clinical Disease Activity Index (CDAI) remission at 12 months resulted in the selection of MIP-1β. Logistic regression using baseline levels of anti-citrullinated protein antibody, IgM-anti-CCP2 positivity, the CDAI, the total power Doppler score, the cluster by cytokines and chemokines, MIP-1β, methotrexate dose and mechanisms of action revealed that cluster by cytokines and chemokines was the sole significant factor for CDAI remission at 12 months. Conclusions: Specific patterns of cytokines and chemokines—no other clinical factors and autoantibody profiles—were important to distinguish patients with RA achieving remission at 12 months. |
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言語 |
en |
| 書誌情報 |
en : RMD Open
巻 11,
号 1,
p. art. no. e005163,
発行日 2025-01-25
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| 出版者 |
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出版者 |
BMJ Publishing Group |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2056-5933 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1136/rmdopen-2024-005163 |
| 権利 |
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権利情報 |
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
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言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
RMD Open, 11(1), art. no. e005163; 2025 |
|
言語 |
en |
RMDO11_e005163.pdf (3.5 MB)
