| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-05-08 |
| タイトル |
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タイトル |
Prevalence of chikungunya virus infection in Sabah, Malaysia during 2017–2020 |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
CHIKV |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Real time PCR |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Neutralization test |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Sabah |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ngwe, Tun Mya Myat
John, Jecelyn Leaslie
Nguyen, Thanh Vu
Mutua, Maurine Mumo
Manah, Abdul Marsudi
Takamatsu, Yuki
Urano, Takeshi
Morita, Kouichi
Ahmed, Kamruddin
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| 抄録 |
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内容記述タイプ |
Other |
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内容記述 |
Background: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus and an emerging global health threat. Most research on CHIKV in Malaysia has primarily focused on Peninsular Malaysia, with limited data on its distribution in the endemic regions of Borneo, particularly Sabah. This study aimed to determine the prevalence of CHIKV infection in Sabah, Malaysia. Methods: A total of 130 serum samples, comprising 74 from febrile patients and 56 healthy individuals were collected between 2017 and 2018. Subsequently, 188 serum samples were obtained from febrile patients in Sabah, Malaysia during 2019–2020. All samples underwent quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) for the detection of the CHIKV genome. Additionally, serological tests were conducted to identify anti-CHIKV IgM and IgG antibodies. Serologically positive samples were further validated using neutralization assays to confirm the presence of CHIKV-specific antibodies. Results: In 2017–2018, 16 out of 130 samples (12.3%) tested positive for recent CHIKV infections based on CHIKV RT-qPCR or anti-CHIKV IgM results, while in 2019–2020, 7 out of 188 samples (3.7%) showed recent infections. Among the 16 recent CHIKV-positive cases in 2017–2018, four were asymptomatic individuals. In 2017–2018, 24 (18.4%) individuals tested positive for anti-CHIKV IgG, with 15 (11.5%) showing positive neutralization test results. In 2019–2020, 20 (10.6%) febrile patients were seropositive for anti-CHIKV IgG, with 17 (9.0%) showing CHIKV neutralization positivity. The CHIKV infection rate in Sabah was higher during 2017–2018 compared to 2019–2020. Conclusions: To the best of our knowledge, this is the first report confirming the presence of CHIKV in both patients and healthy individuals in Sabah using RT-qPCR and neutralization tests. Although the likelihood of transmission from asymptomatic individuals is low, they still present a considerable public health risk. Our results indicate that both basic scientists and clinicians should consider CHIKV when diagnosing febrile patients, and policymakers should put in place effective surveillance and control measures. |
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言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 53,
号 1,
p. art. no. 55,
発行日 2025-04-21
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| 出版者 |
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出版者 |
BioMed Central Ltd |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1349-4147 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s41182-025-00735-3 |
| 権利 |
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権利情報 |
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Tropical Medicine and Health, 53(1), art. no. 55; 2025 |
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言語 |
en |
TMH53_55.pdf (945 KB)
